Comparison of demographic, clinical and interventional variables in the study cohort
| Proximal recanalization | |||
| Yes | No | p Value | |
| (n=26) | (n=16) | ||
| Female gender, n (%) | 21 (81) | 9 (56) | 0.16 |
| Age in years, mean ± SD | 65±20 | 63±18 | 0.79 |
| Clinical history, n (%) | |||
| Cardiac disease | 16 (62) | 6 (38) | 0.20 |
| Hypertension | 16 (62) | 10 (63) | 1 |
| Diabetes | 4 (15) | 6 (38) | 0.14 |
| Prior stroke | 1 (4) | 3 (19) | 0.15 |
| Peripheral vascular disease | 2 (8) | 0 | 0.52 |
| Chronic renal insufficiency | 2 (8) | 1 (6) | 1 |
| Current use of antiplatelets | 5 (19) | 2 (13) | 0.69 |
| Current use of statins | 6 (23) | 3 (19) | 1 |
| Presumed cardioembolism | 23 (88) | 10 (63) | 0.06 |
| Admission glucose (mmol/l) | 7.1±1.6 | 8.4±4.2 | 0.14 |
| Pre-intervention M1a pattern on MR | 15 (68) | 5 (50) | 0.44 |
| Location of initial occlusion | |||
| Proximal M1 | 13 (50) | 7 (44) | 0.76 |
| Middle M1 | 8 (31) | 5 (31) | 1 |
| Distal M1 | 5 (19) | 4 (25) | 0.71 |
| Interventional variables | |||
| Time to intervention (min) | 422±142 | 408±242 | 0.82 |
| Adjuvant intravenous rt-PA | 7 (27) | 4 (25) | 1 |
| Adjuvant intra-arterial rt-PA | 3 (12) | 1 (6) | 1 |
| Intracranial angioplasty and/or stenting | 3 (12) | 2 (13) | 1 |
| Any adjuvant therapy | 11 (42) | 6 (38) | 1 |
| Hemorrhagic transformation | |||
| Asymptomatic | 14 (54) | 5 (31) | 0.21 |
| Symptomatic (including fatal) | 0 | 1 (6) | 0.38 |
| Fatal | 0 | 1 (6) | 0.38 |
| Facilitated endogenous recanalization at 5 h | 12 (46) | 1 (6) | 0.01 |
| Median outcome at discharge, mRS (IQR) | 4 (1–5) | 4 (4–5) | 0.21 |
| Good outcome at discharge (mRS ≤2) | 9 (39) | 0 (0) | 0.01 |
mRS, modified Rankin scale; rt-PA, recombinant tissue plasminogen activator.