Change in PRU values after subsequent clopidogrel dose adjustments
| Clopidogrel dose adjustment (DA) | Number of patients | Mean days after clopidogrel initiation | Mean days after procedure | Mean PRU pre-DA | Mean PRU post-DA | Mean PRU change | Patients within target 60–240 PRU range after DA |
|---|---|---|---|---|---|---|---|
| Second DA: | 24 | 40 | 25 | 29 | 92 | +63 | 71% |
| 150mg daily to 75mg daily (n = 1) or 75mg every-other-day (n = 1) | 2 | 43 | 106 | +63 | 100% | ||
| 75 mg every-other-day to 75 mg every-third-day (n = 9) or 75 mg every-Monday-and-Friday (n = 3) | 12 | 33 | 72 | +39 | 58% | ||
| 75 mg every-third-day to 75 mg every-Monday-and-Friday (n = 3), 75mg every-fifth-day (n = 4) or 75mg once-a-week (n = 1) | 8 | 24 | 119 | +95 | 88% | ||
| 75 mg every-Monday-and-Friday to 75 mg once-a-week (n = 1) or 7.5 mg daily suspension (n = 1) | 2 | 7 | 87 | +80 | 50% | ||
| Third DA | 7 | 47 | 31 | 33 | 115 | +82 | 57% |
| 75 mg every-third-day to 75 mg every-fourth-day (n = 3) or 75 mg every-Monday-and-Friday (n = 3) | 6 | 37 | 105 | +68 | 50% | ||
| 75 mg every-Monday-and-Friday to 75 mg once-a-week | 1 | 9 | 178 | +169 | 100% | ||
| Fourth DA, 75 mg every-fourth-day to 75 mg every-fifth-day | 1 | 39 | 29 | 42 | 155 | +113 | 100% |