Table 1

Characteristics of the six included studies

 Enrollment criteria
TrialTrial periodLocationNo of centersTime from symptom onsetAge (years)NIHSS
PROACT II101996–1998North America54<6 h18–854–30
MELT112002–2005Japan57<6 h20–755–22
IMS III22006–2012North America, Europe, Australia58<3 h18–82≥10 (≥8)*
SYNTHESIS42008–2012Europe24<4.5 h18–80Any
MR RESCUE32004–2011North America22<8 h18–856–29
MR CLEAN82010–2014Europe30<6 h≥18≥2
  • *NIHSS of 8–9 was allowed in an amendment if large vessel occlusion in internal carotid or middle cerebral artery was documented on CT angiography.

  • IMS, Interventional Management of Stroke; MR RESCUE, Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy; NIHSS, National Institutes of Health Stroke Severity score.