Table 1

Brief summary of recently published trials comparing best medical therapy alone with best medical therapy plus embolectomy

Number randomized50070315
Inclusion criteria
 NIHSS range2+2+6+
 Time from onset to groin puncture0–6 h0–6 h0–12 h
 Imaging required prior to treatmentNCCT, CTA/MRANCCT, CTA/MRA, CTP/MRPNCCT, CTA
 Imaging exclusion criteria (other than acute hemorrhage)NoneIschemic core <70 mL on CTP or MRINCCT ASPECTS <6, CTA with no collateral filling
 Target imaging to groin punctureNot specifiedNot specifiedNCCT to puncture <60 min
 mRS 0–2, medical19.1%40%29.3%
 mRS 0–2, medical+IAT32.6%71%53%
 Recanalization (% TICI 2b/3)58.7%86%72.4%
 Number needed to treat to have one additional patient independent at 90 days44
  • ASPECTS, Alberta Stroke Program Early CT Score; CTA, CT angiography; CTP, CT perfusion; IAT, intra-arterial thrombolysis; MRA, MR angiography; MRP, MR perfusion; mRS, modified Rankin Scale; NCCT, non-contrast CT; TICI, Thrombolysis In Cerebral Ischemia.