Patient characteristics in the derivation and validation cohorts
| Patient characteristics | GMH (derivation) N=247 | UPMC (validation 1) N=393 | UIVH (validation 2) N=204 | p Value |
|---|---|---|---|---|
| Age, mean±SEM | 65.7±0.9 | 66.4±0.7 | 71±1 | <0.001 |
| Sex, N (% male) | 140 (52.8) | 187 (47.6) | 113 (55.4) | 0.045 |
| NIHSS, median (IQR) | 18 (15–23) | 16 (12–20) | 19 (17–21) | <0.001 |
| ASPECTS, median (IQR) | 8 (7–9) | 9 (7–10) | 9 (9–10) | <.001 |
| DM, N (%) | 67 (27.0) | 85 (21.6) | 36 (17.7) | 0.03 |
| HTN, N (%) | 180 (72.6) | 256 (65.1) | 132 (64.7) | 0.04 |
| Atrial fibrillation, N (%) | 80 (32.3) | 127 (32.4) | 90 (44.1) | 0.02 |
| ICA, N (%) | 58 (23.5) | 100 (25.5) | 74 (36.3) | 0.004 |
| M1 MCA, N (%) | 158 (63.9) | 249 (63.4) | 116 (56.9) | 0.22 |
| M2 MCA, N (%) | 31 (12.6) | 44 (11.1) | 14 (6.9) | 0.13 |
| TLSW to groin puncture (min), mean±SEM | 324±10.6 | 336.4±32 | 225±7 | <0.001 |
| IV tPA, N (%) | 132 (53.4) | 171 (43.5) | 119 (58.3) | 0.001 |
| sICH rate, N (%) | 18 (7.3) | 25 (6.4) | 19 (9.3) | 0.4 |
| Infarct volume (mL), median (IQR) | 38 (17–89) | 64 (22–164) | 35 (8–150) | 0.001 |
| 90-day mRS, median (IQR) | 3 (2–6) | 4 (2–6) | 4 (1–6) | 0.28 |
χ2 analysis was used to compare rates of occurrence of categorical variables. Age, TLSW to groin were compared using the Kruskal–Wallis test. Medians (for NIHSS, ASPECTS, infarct volume, mRS at 90 days) were compared using the Independent Samples Median test. p<0.05 was considered significant.
ASPECTS, Alberta Stroke Program Early CT Score; DM, diabetes mellitus; GMH, Grady Memorial Hospital; HTN, hypertension; ICA, internal carotid artery; IV, intravenous; MCA, middle cerebral artery; mRS, modified Rankin scale score; NIHSS, National Institute of Health Stroke Scale; sICH, symptomatic intracerebral hemorrhage; tPA, tissue plasminogen activator; TLSW, time from last-seen-well; UMPC, University of Pittsburgh Medical Center.