Comparison of recent studies with posterior circulation flow diverter treatment
| First author (year) | Number of posterior circulation aneurysms | Mean age | Flow diverter type | Aneurysm type | Aneurysm location | Symptomatic (%) | Recurrent aneurysm (%) | Average max diameter (mm) | Average stent/patient | Additional coiling (%) | Patients available for F/U (%) | Avg F/U (months) | Complete occlusion at F/U (%) | Mortality (%) | Permanent neurologic deficit (%) | mRS 0–2 (%) | Ruptured (%) | Antiplatelet testing |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Byrne JV (2010)6 | 20 (+50 anterior circulation aneurysms) | N/A | Silk | 11 fusiform, 9 saccular | 5 basilar trunk, 1 SCA, 2 AICA, 2 PICA, 10 vertebral | 57 | N/A | 35% sized >25 mm, 35% 10–25 mm, 30% <10 mm | N/A | 14* | 72* | N/A | 49* | 10 | 5 | 85† | 14.3* | No |
| Siddiqui A (2012)7 | 7 | 55.4 | 6 Pipeline, 1 Silk/Leo | 6 fusiform, 1 fusiform–sacccular | 7 basilar | 100.0 | 0 | 20.8 | 5 | 57.1 | 100 | N/A | N/A | 57 | 14 | 28.6 | 0 | Yes |
| Philips TJ (2012)9 | 32 | 52 | Pipeline | 12 saccular, 20 fusiform, blister, sidewall or dissecting | 8 basilar, 11 basilar tip-P1, 2 VBJ, 7 vertebral, 1 PICA, 3 PCA | 37.5 | 34.4 | 9.7 | 1.5 | 34.4 | 71.9% at 12 months; 25% at 24 months | 14† | 96 | 0 | 9.4 | 100 | 25 | in 1/3 centers |
| Kulcsar Z (2012)10 | 12 | 49 | Silk | N/A | 4 basilar tip, 6 basilar trunk, 3 SCA | 50 | 25.0 | 11.5 | 1.1 | 50.0 | 58 | 4 | 100 | 0 | 25 | 75 | 8.3 | No |
| Fischer S (2012)5 | 22 (+79 anterior circulation aneurysms) | 59* | Pipeline | 63 saccular, 33 fusiform, 5 dissections* | N/A | 40* | N/A | 3.8* | 3* | 3* | 48.5* | 10* | 64* | 4.5 | 9.1 | 91* | 18* | VerifyNow or Multiplate |
| Chalouhi N (2013)8 | 7 | 63 | Pipeline | 4 saccular, 3 fusiform | 3 verterbral, 2 VBJ, 2 basilar | 28.6 | 42.9 | 14.1 | 1.6 | 14.3 | 86 | 5.5 | 43 | 0 | 0 | 86 | 0 | VerifyNow |
| Current study (2014) | 7 | 51.4 | Pipeline | 5 saccular, 2 fusiform | 3 vertebral, 3 basilar, 1 PCA | 85.7 | 14.3 | 18.1 | 2 | 42.9 | 100 | 14.5 | 57.1‡ | 14.3 | 14.3 | 71 | 0 | Platelet aggrego-metry |
| Total | 107 | |||||||||||||||||
| Mean* | 15.3 | 55* | 57* | 23.3 | 13.0* | 2.4* | 30.8* | 77.4* | N/A | 68.2* | 12.3 | 11.0 | 72.1* | 9.4 | ||||
| Mean for posterior circulation | 15.3 | 54.2 | 59.8 | 23.3 | 14.8 | 2.2 | 39.7 | 83.2 | 9.5 | 74 | 12.3 | 11.0 | 74.3 | 6.7 |
*Includes anterior circulation aneurysms.
†Estimated number.
‡No evidence of residual aneurysm filling due to complete thrombosis of the entire Pipeline construct secondary to medication non-compliance in one case.
AICA, anterior inferior cerebellar artery; F/U, follow-up; mRS, modified Rankin score; N/A, data not available; PCA, posterior cerebral artery; PICA, posterior inferior cerebellar artery; SCA, superior cerebellar artery; VBJ, vertebrobasilar junction.