Table 1

Demographic, clinical, and imaging features of patient population. Data are presented with findings at BIPSS and surgery

Age (range)	Clinical symptoms	MRI results	Central-izing BIPSS	Lateralization on BIPSS	Treatment	Pathology	Clinical result
60s	Hypertension, osteoporosis, central obesity, diabetes	Right inferior 4–5 mm nodule	Yes	Right	Tumor resection	Right adenoma	Remission
30s	Hypercortisolism, acne, chronic pain, diabetes	Left sellar 7 mm partly cystic nodule	Yes	Left	Tumor resection	Left adenoma	Remission
30s	Weight gain, rounded facies, buffalo hump	Central inferior 2–3 mm nodule and far right sellar cystic nodule	Yes	Right	Tumor resection	Right adenoma	Remission
10s	Delayed growth, cushingoid habitus	Normal	Yes	Right	Tumor resection	Right adenoma	Remission
40s	Weight gain, buffalo hump, fatigue, weakness, decreased bone density	Subtle abnormality inferiorly	Yes	Left	Tumor resection	Right adenoma	Remission
10s	Growth failure, obesity, facial plethora, acne	Normal	Yes	Right	Tumor resection	Right adenoma	No follow-up
20s	Hypothyroidism, weight gain, striae	Normal	Yes	Left	Tumor resection	Inferior adenoma	Remission
20s	Memory loss, weight gain, irregular menses, hypertension, hirsutism, easy bruising, striae, buffalo hump, supraclavicular fat	Left sellar 6 mm nodule	Yes	Right	Tumor resection	Left adenoma	Remission
60s	Weight gain, diabetes, hypertension, chronic renal failure	Normal	Yes	Right	Tumor resection	Right adenoma	Remission
30s	Weight gain, fatigue, depression, anxiety	Right sellar 8–9 mm cystic abnormality	Yes	None	Tumor resection	Right adenoma	Remission
20s	Weight gain, striae, facial hair, amenorrhea, diabetes	Left sellar 4 mm abnormality	Yes	Right	Tumor resection	Left adenoma	Remission
30s	Weight gain, buffalo hump, hirsutism	Inferior right sellar nodule	Yes	Left	Tumor resection	Right adenoma	Remission
40s	Hypertension, diabetes, central weight gain, acne, facial rounding, supraclavicular fat	Right lateral sellar abnormality	Yes	None	Tumor resection	Central/right adenoma	Remission
50s	Fatigue, weakness, bruising, emotional liability, round face	Normal	Yes	Right	Tumor resection	Right adenoma	Remission
30s	Amenorrhea, central weight gain, round face, easy bruising, muscle weakness, joint and back pain, fatigue	Right pituitary nodule	Yes	Right	Tumor resection	Right adenoma	Remission
40s	Fatigue, anxiety, facial hirsutism, prolonged bruising, irregular menses, acne, weight loss	Normal	No	None	No follow-up
60s	Anxiety, hypertension, easy bruising, hair loss	Possible left pituitary lesion	Yes	Left	No surgery		Ongoing symptoms
80s	Hypertension, hypercortisolemia	Midline 4–5 mm nodule	Yes	Left	Tumor resection	Left adenoma	Remission
10s	Hypercortisolemia with growth retardation, early puberty and evidence of Cushing disease	Possible right pituitary nodule	Yes	Right	Tumor resection	Right adenoma	Remission
20s	Central obesity, high blood pressure, easy bruising, striae, oligomenorrhea, dysthymia	Possible central nodule	No	None	Tumor resection	Right adenoma	Remission

BIPSS, bilateral inferior petrosal sinus sampling.