Heterogeneity and pooled estimates in primary syntheses and sensitivity analyses
| Outcome | Q | I2 (%) | τ2 | p Value | RR (95% CI)/ MWP (95% CI) | Qual-adj RR (95% CI) | Pub bias-adj RR (95% CI) |
|---|---|---|---|---|---|---|---|
| DoD | 44.2 | 18.6 | 0.007 | 0.16 | 0.67 (0.62 to 0.72) | 0.67 (0.63 to 0.71) | 0.72 (0.68 to 0.76) |
| DoD ≤12 h | 9.3 | 0.0 | 0.000 | 0.58 | 0.63 (0.54 to 0.74) | ||
| DoD >12 h | 33.5 | 28.5 | 0.010 | 0.09 | 0.67 (0.62 to 0.73) | ||
| DoD IVT | 3.2 | 6.4 | 0.002 | 0.36 | 0.68 (0.57 to 0.80) | ||
| DoD IA/EVT | 40.9 | 21.9 | 0.008 | 0.13 | 0.67 (0.61 to 0.72) | ||
| Mortality | 45.4 | 16.4 | 0.018 | 0.18 | 0.49 (0.44 to 0.55) | 0.49 (0.44 to 0.54) | 0.50 (0.46 to 0.55) |
| Mortality ≤12 h | 13.3 | 9.8 | 0.023 | 0.34 | 0.46 (0.35 to 0.60) | ||
| Mortality >12 h | 31.6 | 21.0 | 0.019 | 0.16 | 0.50 (0.44 to 0.56) | ||
| Mortality IVT | 2.04 | 0.0 | 0.000 | 0.56 | 0.53 (0.40 to 0.70) | ||
| Mortality IA/EVT | 43.2 | 21.4 | 0.025 | 0.13 | 0.48 (0.42 to 0.55) | ||
| ICH | 123.3 | 65.9 | 0.010 | <0.0001 | 13% (10 to 16) | 14% (13 to 16) | No pub bias found |
| ICH ≤12h | 23.4 | 48.7 | 0.007 | 0.02 | 10% (5 to 15) | ||
| ICH >12h | 88.2 | 67.1 | 0.009 | <0.0001 | 14% (11 to 18) | ||
| ICH IVT | 12.3 | 75.7 | 0.011 | 0.006 | 9% (2 to 18) | ||
| ICH IA/EVT | 107.6 | 64.7 | 0.010 | <0.0001 | 14% (10 to 17) |
DoD, death or dependency; I2, percentage of total variance attributable to heterogeneity; IA/EVT, intra-arterial/endovascular therapy; ICH, intracerebral hemorrhage; IVT, intravenous thrombolysis; MWP, mean weighted probability; p, p value for heterogeneity; Pub bias-adj, publication bias adjusted; Q, Cochran's Q; Qual-adj, quality adjusted; RR, risk ratio; τ2, between study variance.