Year—Author | Delivery method | Description | Features |
---|---|---|---|
2015—Samiotaki et al46 2014—Nance et al47 2012—Etame et al37 2013—Burke et al38 2014—Christian et al42 | Thermomechanical disruption of BBB with focused ultrasound and intravenous administration of a microbubble solution | Safe, transient, localized disruption of the BBB with subsequent administration of chemotherapy | Non-invasive Relatively economical |
2014—Nance et al47 2013—Burke et al38 2014—Bernal et al50 2014—Lee Titsworth et al51 | Nanoparticles activated by thermomechanical (eg, magnetic) stereotactic stimulation | Nanoparticle—chemotherapeutic agent complexes cross the BBB through simple diffusion from convection-enhanced delivery or intraventricular or intrathecal source | Non-invasive Cost |
2008—Dietrich et al52 2012—Altanernova et al53 2013—Lee et al54 2013—Metz et al55 2014—Teng et al56 | Stem cell-mediated delivery | Mesenchymal stem cells have natural tropism for brain tumor cells and are used as vectors of cytotoxic molecules, synthetic microRNA | Cost |
BBB, blood–brain barrier.