Table 2

Meta-analysis of ruptured aneurysm comparing coiling and clipping (short-term to long-term follow-up, OR for a functional outcome <1 favors coiling, OR for adverse outcomes >1 favors coiling)

Independent outcomeMortalityPoor outcome
No of studies includedEffect estimate (95% CI)HeterogeneityNo of studies includedEffect estimate (95% CI)HeterogeneityNo of studies includedEffect estimate (95% CI)Heterogeneity
Short-term outcome (at discharge to 3 months’ follow-up)
 RCT30.67 (0.57 to 0.79)p=0.56; I²=0%21.09 (0.79 to 1.50)p=0.75; I²=0%31.53 (1.29 to 1.81)p=0.46; I²=0%
 Observational studies211.12 (0.83 to 1.52) p<0.0000; I²=77%170.76 (0.50 to 1.15)p< 0.0001; I²=69%211.14 (1.00 to 1.30)p<0.00001; I²=80%
 Database registry studies31.02 (0.87 to 1.18)p=0.13; I²=52%40.88 (0.80 to 0.96)p=0.11; I²=50%30.98 (0.85 to 1.14)p=0.13; I²=52%
Test for subgroup differences: p, I²Test for subgroup differences: p, I²Test for subgroup differences: p, I²
 Overall effectNANANANA0.84 (0.72 to 0.98)p=0.34, I²=8.0%NANANA
Intermediate outcome (>3 months to 1-year follow-up)
 RCT40.69 (0.59 to 0.81)p=0.97; I²=0%31.29 (0.98 to 1.69)p=0.95; I²=0%40.69 (0.59 to 0.82)p=0.98; I²=0%
 Observational studies240.82 (0.71 to 0.96)p=0.06; I²=33%180.93 (0.67 to 1.31)p=0.33; I²=10%241.15 (1.03 to 1.28)p=0.04; I²=38%
Test for subgroup differences: p, I²Test for subgroup differences: p, I²Test for subgroup differences: p, I²
 Overall effect280.80 (0.68 to 0.94)p=0.17, I²=47.4%211.13 (0.92 to 1.40)p=0.33; I²=11%281.26 (1.07 to 1.48)p=0.20, I²=37·9%
Long-term outcome (>1-year follow-up)
 RCT20.80 (0.69 to 0.94)p=0.38; I²=0%11.39 (1.09 to 1.77)NA21.25 (1.06 to 1.46)p=0.38; I²=0%
 Observational studies90.84 (0.63 to 1.10)p=0.47; I²=0%80.71 (0.48 to 1.06)p=0.34; I²=12%91.44 (1.06 to 1.95)p=0.57; I²=0%
Test for subgroup differencesTest for subgroup differencesTest for subgroup differences
 Overall effect110.81 (0.71 to 0.93)p=0.80, I²=0%NANANA111.29 (1.12 to 1.48)p=0.62; I²=0%
  • RCT, randomized controlled trial.