Treatment details, complications and clinical outcome
| Patients with MT and IVT (n=105) | Patients with MT and no IVT (n=145) | p Value | Patients with MT alone without contraindications for IVT (n=70) | Patients with MT alone with contraindications for IVT (n=75) | p Value | |
|---|---|---|---|---|---|---|
| Symptom-to-groin puncture-time* (min), median (IQR) | 233 (198–295) | 210 (152–330) | 0.103 | 183 (132–225) | 271 (177–543) | <0.001 |
| First imaging-to-groin puncture time (min), median (IQR) | 148 (122–167) | 112 (60–153) | <0.001 | 85 (51–141) | 131 (89–164) | 0.022 |
| Symptom-to-end-of-thrombectomy time*, (min), median (IQR) | 280 (233–370) | 272 (193–401) | 0.221 | 231 (169–296) | 325 (323–672) | <0.001 |
| Successful recanalization (TICI score 2b/3), n (%) | 76 (73.8) | 106 (73.1) | 0.952 | 52 (74.3) | 54 (74) | 0.966 |
| Number of passes of the thrombectomy device, median (min–max) | 1 (1–11) | 2 (0–9) | 0.904 | 2.0 (0–9) | 2.0 (1–9) | 0.605 |
| Embolus in further vessel territory, n (%) | 6 (5.7) | 5 (3.4) | 0.374 | 2 (2.9) | 3 (4.0) | 0.684 |
| Iatrogenic vessel dissection, n (%) | 7 (6.7) | 4 (2.8) | 0.238 | 3 (4.3) | 1 (1.3) | 0.304 |
| Subarachnoidal hemorrhage, n (%) | 3 (2.9) | 4 (2.8) | 0.947 | 1 (1.4) | 3 (4.0) | 0.331 |
| Groin hematoma, n (%) | 2 (1.9) | 2 (1.4) | 0.732 | 1 (1.4) | 1 (1.3) | 0.976 |
| Symptomatic ICH, n (%) | 6 (5.9) | 5 (3.5) | 0.387 | 2 (2.9) | 3 (4.1) | 0.708 |
| Any ICH†, n (%) | 18 (17.6) | 22 (15.6) | 0.671 | 9 (13.2) | 13 (17.3) | 0.455 |
| Favorable outcome (mRS 0–2) at follow-up, n (%) | 37 (35.2) | 58 (40.0) | 0.444 | 34 (48.6) | 24 (32.0) | 0.042 |
| Mortality at follow-up, n (%) | 28 (26.7) | 46 (31.7) | 0.3387 | 18 (25.7) | 28 (37.3) | 0.133 |
*Stroke symptom onset or last time point patient seen well.
†Including both asymptomatic and symptomatic ICH.
ICH, intracranial hemorrhage; IVT, intravenous thrombolysis; MT, mechanical thrombectomy; mRS, modified Rankin Scale; TICI, Thrombolysis in Cerebral Infarction Score.