Table 3

Meta-analysis of unruptured aneurysm comparing surgical clipping and endovascular coiling (short-term to long-term follow-up, OR for a functional outcome <1 favors coiling, OR for adverse outcomes >1 favors coiling)

Indepedent outcomeMortalityPoor outcome
No of studies includedEffect estimate (95% CI)HeterogeneityNo of studies includedEffect estimate (95% CI)HeterogeneityNo of studies includedEffect estimate (95% CI)Heterogeneity
Short-term outcome (at discharge to 3 months’ follow-up)
 Observational studies120.77 (0.56 to 1.07)p=0.60; I²=0%110.88 (0.48 to 1.62)p=0.79; I²=0%121.27 (0.92 to 1.76)p=0.28; I²=18%
 Database registry studies90.34 (0.29 to 0.41)p<0.00001; I²=89%91.74 (1.52 to 1.98)p=0.11; I²=38%92.91 (2.42 to 3.51)p<0.00001; I²=89%
Test for subgroup differencesTest for subgroup differencesTest for subgroup differences
 Overall effectNANANANANANA
Intermediate outcome (>3 months to 1-year follow-up)
 Observational studies111.07 (0.72 to 1.57)p=0.68; I²=0%110.71 (0.41 to 1.24)p=0.44; I²=0%110.95 (0.64 to 1.40)p=0.69; I²=0%
Test for subgroup differencesTest for subgroup differencesTest for subgroup differences
 Overall effectNANANANANANA
Long-term outcome (>1-year follow-up)
 Observational studies53.01 (1.14 to 7.99)p=0.46; I²=0%60.45 (0.09 to 2.33)p=0.12; I²=52%50.33 (0.13 to 0.88)p=0.46; I²=0%
 Database registry studiesNANANA20.96 (0.78 to 1.18)p=0.85; I²=0%NANANA
Test for subgroup differencesTest for subgroup differences: p, I²Test for subgroup differences: p, I²
 Overall effectNANA0.94 (0.77 to 1.15)p=0.43, I²=0%NANA