Table 1

Summary of previously published studies using distal aspiration or proximal balloon occlusion and comparison with recently published randomized trials (MR CLEAN, EXTEND IA)

Author, yearBalloon occlusionDistal aspirationNProcedure time (min)Final TICI ≥2b (%)ENT (%)mRS ≤2 at 3 months (%)
Pereira et al (STAR) 201319YesNo2022088.11.057.9
Nguyen et al (NASA) 201414YesNo14912075.2551.6
Campell et al (EXTEND IA) 20155Yes*No354386671
Delgado Almandoz et al 201515NoYes, Solumbra555184231
Humphries et al 201513NoYes, Solumbra10554885.744.1
Turk et al 201412NoYes, ADAPT9837ADAPT: 78, plus stent retriever 950, but in 10 downstream emboli40
Delgado Almandoz et al 201515NoYes, ADAPT455089†456
Berkhemer et al (MR CLEAN) 20151233?58.78.632.6
  • *Use of balloon occlusion was recommended.

  • †Solumbra salvage had to be employed in 29% of the ADAPT cases.

  • ‡Unknown.

  • ADAPT, a direct aspiration first pass technique; ENT, embolization into a new territory; mRS, modified Rankin Scale; n, number of patients; TICI, Thrombolysis In Cerebral Infarction score; Solumbra, aspiration plus stent retriever.