Overview of included patients
| Working-hours | Out-of-hours | p Value | |
|---|---|---|---|
| Demographics | |||
| Age (years), mean±SD | 71.6±14.5 (median 74.9; IQR 17.2) | 70.3±14.0 (median 72.0; IQR 16.0) | 0.143 |
| Male sex | 84/166 (50.6) | 121/240 (50.4) | 0.971 |
| Medical history | |||
| Hypertension | 132/166 (79.5) | 189/240 (78.8) | 0.852 |
| Diabetes | 46/166 (27.7) | 59/240 (24.6) | 0.479 |
| Fat metabolism disorder | 50/166 (30.1) | 71/240 (29.6) | 0.907 |
| Adiposity | 46/166 (27.7) | 61/240 (25.4) | 0.606 |
| Nicotine | 37/166 (22.3) | 64/240 (26.7) | 0.316 |
| Alcohol | 6/166 (3.6) | 8/240 (3.3) | 0.879 |
| Cardiovascular disease | 87/166 (52.4) | 114/240 (47.5) | 0.331 |
| Atrial fibrillation | 79/166 (47.6) | 113/240 (47.1) | 0.920 |
| Prior stroke | 38/166 (22.9) | 42/240 (17.5) | 0.179 |
| Current antiplatelet use | 50/154 (32.5) | 74/223 (33.2) | 0.884 |
| Current anticoagulant use | 22/166 (13.3) | 32/240 (13.3) | 0.981 |
| Stroke etiology | |||
| Cardioembolic | 92/166 (55.4) | 132/240 (55.0) | 0.932 |
| Atherosclerosis | 40/166 (24.1) | 59/240 (24.6) | |
| Concurring | 8/166 (4.8) | 14/240 (5.8) | |
| Undetermined/undeterminable | 16/166 (9.6) | 16/240 (6.7) | |
| Other | 10/166 (6.0) | 18/240 (7.5) | |
| Clinical baseline | |||
| NIHSS on admission, mean±SD | 17.7±7.2 (median 18.0; IQR 7) | 16.6±6.8 (median 17.0; IQR 8) | 0.133 |
| Site of vessel occlusion | |||
| Extracranial ICA | 20 (12.0) | 24 (10.0) | 0.704* |
| MCA | 87 (52.4) | 109 (45.4) | |
| ICA and MCA | 28 (16.9) | 67 (27.9) | |
| ACA | 3 (1.8) | 0 (0.0) | |
| ICA and ACA | 0 (0.0) | 1 (0.4) | |
| MCA and ACA | 6 (3.6) | 1 (0.4) | |
| VA | 3 (1.8) | 3 (1.3) | |
| BA | 19 (11.4) | 29 (12.1) | |
| PCA | 0 (0.0) | 3 (1.3) | |
| Initial ASPECTS, mean±SD | 8.7±1.5 (median 9.0; IQR 2) | 9.0±1.5 (median 9.0; IQR 2) | 0.090 |
| Time intervals | |||
| Onset to door, mean±SD | 103.7±86.3 (median 82.0; IQR 83) | 106.0±87.0 (median 76.0; IQR 89) | 0.905 |
| Door to image, mean±SD | 26.5±13.3 (median 25.0; IQR 12) | 28.2±12.8 (median 27.0; IQR 12) | 0.309 |
| Image to puncture, mean±SD | 59.7±47.3 (median 53.0; IQR 33) | 60.6±26.5 (median 55.0; IQR 27) | 0.110 |
| Puncture to revascularization, mean±SD | 79.6±56.4 (median 62.5; IQR 65) | 80.1±48.5 (median 64.5; IQR 62) | 0.372 |
| Door to revascularization, mean±SD | 162.2±78.1 (median 148.0; IQR 93) | 172.1±65.9 (median 161.0; IQR 76) | 0.054 |
| Onset to revascularization, mean±SD | 243.0±102.4 (median 229.5; IQR 119) | 258.2±104.2 (median 232.0; IQR 119) | 0.400 |
| Interventional procedures | |||
| Systemic thrombolysis | 106/166 (63.9) | 157/240 (65.4) | 0.746 |
| IA thrombolysis | 37/166 (22.3) | 48/240 (20.0) | 0.577 |
| Mechanical | 135/166 (81.3) | 198/240 (82.5) | 0.762 |
| Mechanical+systemic | 82/166 (49.4) | 127/240 (52.9) | 0.485 |
| Mechanical+IA | 25/166 (15.1) | 35/240 (14.6) | 0.894 |
| Outcome | |||
| Successful revascularization (TICI ≥2b) | 125/147 (85.0) | 171/211 (81.0) | 0.326 |
| Good clinical outcome (mRS ≤2 d90) (all) | 35/137 (25.5) | 66/198 (33.3) | 0.127 |
| Death (mRS=6) d90 (all) | 55/137 (40.1) | 62/198 (31.3) | 0.095 |
| Good clinical outcome (EST group) (mRS≤2 d90) | 32/123 (26.0) | 62/176 (35.2) | 0.091 |
| Death (mRS=6) d90 (EST group) | 48/123 (39.0) | 53/176 (30.1) | 0.109 |
Values are expressed as number (%) if not indicated otherwise.
*Statistical analysis was based on whether occlusions were located in the anterior or posterior circulation.
ACA, anterior cerebral artery; ASPECTS, Alberta stroke program early CT score; BA, basilar artery; EST, endovascular stroke treatment; IA, intra-arterial; ICA, internal carotid artery; MCA, middle cerebral artery; mRS, modified Rankin scale; NIHSS, National Institute for Health Stroke Scale; PCA, posterior cerebral artery; TICI, Thrombectomy in Cerebral Infarction; VA, vertebral artery.