Table 1

Summary of included studies

Outcome studied	Author, year	No of patients	Therapy type	Histological techniques	Imaging techniques
Histology and etiology	Simons, 2015	40	MT	H&E and CD34	CT
	Kim, 2015	37	MT	H&E, PGPIIIa, CD61	MRI
	Singh, 2014	49	MT	H&E	NA
	Niesten, 2014	22	MT	H&E, Mallory's phosphotungistic acid-hematoxilin, glyophorin A, CD31	CT
	Boekh-Behrens, 2014	54	MT	H&E, Elastica van Gieson	CT
	Sallustio, 2014	28	MT	H&E	NA
	Sato, 2012	17	None	H&E, PGPIIb/IIIa, glycophorin A and FibII	NA
	Liebeskind, 2011	50	MT	H&E	CT/MRI
	Marder, 2006	25	MT	H&E	NA
Histology and angiographic outcomes	Boekh-Behrens, 2014	54	MT	H&E, Elastica van Gieson	CT
	Liebeskind, 2011	50	MT	H&E	CT/MRI
	Marder, 2006	25	MT	H&E	NA
	Qureshi, 2015	19	MT	H&E	NA
Imaging and histology	Simons, 2015	40	MT	H&E and CD34	CT
	Kim, 2015	37	MT	H&E, PGPIIIa, CD61	MRI
	Niesten, 2014	22	MT	H&E, Mallory's phosphotungistic acid-hematoxilin, glyophorin A, CD31	CT
	Liebeskind, 2011	50	MT	H&E	CT/MRI
	Cline, 2013	16	MT	H&E	CT
	Lopez-Cancio, 2013	15	MT	Fibrinogen, PAI-1, P-selectin, VWf	CT
	Boekh-Behrens, 2014	54	MT	H&E, Elastica van Gieson	CT
	Ahn, 2012	16	MT	H&E	CT
Imaging and outcome of IA therapy	Moftakher, 2013	77	MT	NA	CT
	Kim, 2006	34	IA tPA	NA	CT
	Mokin, 2015	41	MT	NA	CT
	Soize, 2015	113	MT	NA	MRI
	Liebeskind, 2011	50	MT	H&E	CT/MRI
	Froehler, 2013	67	MT	NA	CT
	Spiotta, 2014	95	MT	NA	CT
	Vijiaratnam, 2015	181	MT	NA	CT
Imaging and etiology	Topcuoglu, 2015	105	IV-tPA or IA-tPA	NA	CT
	Froehler, 2013	67	MT	NA	CT
	Puig, 2012	45	IV-tPA	NA	CT
	Kim, 2006	34	IA/IV-tPA	NA	CT
	Almekhlafi, 2011	264	IA/IV	NA	CT/MRI
	Guthrie, 2012	128	NA	NA	CT
	Cho, 2005	95	NA	NA	MRI

IA, intra-arterial; IV, intravenous; MT, mechanical thrombectomy; NA, not applicable; tPA, tissue plasminogen activator.