Baseline characteristics, safety and effectiveness outcomes of the study population stratified according to compliance with AHA recommendations for MT in relation to location of intracranial occlusion and elapsed time between symptom onset and groin puncture
| Outcome variable | Cases meeting AHA recommendations for location of intracranial occlusions | Cases meeting AHA recommendations for time of onset to groin puncture | ||||
|---|---|---|---|---|---|---|
| Yes* (n=439) | No† (n=144) | p Value | Yes‡ (n=475) | No§ (n=108) | p Value | |
| Median (IQR) onset to groin puncture time, min | 220 (165–307) | 287 (217–378) | 0.064 | 205 (156–266) | 439 (395–632) | <0.001 |
| Median (IQR) groin puncture to recanalization time, min | 41 (24–62) | 41 (26–60) | 0.942 | 41 (24–62) | 41 (21–64) | 0.183 |
| Complete recanalization, % | 70 | 65 | 0.249 | 69 | 69 | 0.880 |
| Median (IQR) relative reduction in NIHSS score at discharge¶, % | 68 (33–88) | 60 (−4–91) | 0.745 | 71 (30–91) | 60 (23–83) | 0.033 |
| mRS 0–2 at 3 months**, % | 44% | 42% | 0.637 | 46% | 34% | 0.040 |
| sICH, % | 10% | 4% | 0.029 | 7% | 14% | 0.029 |
| Other complications, %†† | 5% | 5% | 0.943 | 6% | 4% | 0.330 |
| Mortality at 3 months‡‡, % | 20% | 34% | 0.002 | 23% | 28% | 0.296 |
*Occlusions in terminal ICA, MCA M1 segment, tandem ICA/MCA occlusion.
†Occlusions in M2 MCA, M3 MCA, anterior cerebral artery, posterior circulation occlusions.
‡Onset to groin puncture time <6 hours.
§Onset to groin puncture time >6 hours.
¶Relative reduction in NIHSS score at discharge was calculated as follows: [(Admission NIHSS –Discharge NIHSS)×100]/Admission NIHSS.
**Three-month functional outcome was available in 510 patients. There were 73 cases with missing 3-month follow-up data.
††Other complications including transient vasospasm, groin hematoma, vessel dissection and/or perforation.
‡‡Three-month mortality data were available in 510 patients. There were 73 cases with missing 3-month mortality data.
AHA, American Heart Association; ICA, internal carotid artery; MCA, middle cerebral artery; mRS, modified Rankin Scale; MT, mechanical thrombectomy; NIHSS, NIH Stroke Scale; sICH, symptomatic intracerebral hemorrhage.