Baseline characteristics and outcomes (effectiveness and safety) of the study population stratified according to compliance with top-tier AHA evidence for MT
| Variable | Total number (n=583) | Cases meeting top-tier AHA evidence for MT (n=349)* | Cases not meeting top-tier AHA evidence for MT (n=234)† | p Value |
|---|---|---|---|---|
| Baseline characteristic | ||||
| Mean±SD age, years | 62±19 | 63±18 | 62±19 | 0.552 |
| Male gender, n (%) | 289 (50%) | 165 (47%) | 124 (53%) | 0.176 |
| Median (IQR) pretreatment NIHSS score, points | 17 (12-21) | 17 (14–21) | 16 (9–21) | 0.006 |
| Pretreatment with IV thrombolysis, n (%) | 292 (50%) | 198 (57%) | 94 (40%) | <0.001 |
| Median (IQR) onset to groin puncture time, min | 232 (170–325) | 191 (155–247) | 365 (251–451) | <0.001 |
| Effectiveness outcomes | ||||
| Median (IQR) groin to recanalization time, min | 40 (24–64) | 41 (24–61) | 41 (26–62) | 0.762 |
| Complete recanalization, n (%) | 403 (69%) | 249 (71%) | 154 (66%) | 0.156 |
| Median (IQR) relative reduction in NIHSS score at discharge,‡ % | 63 (26–88) | 75 (44–91) | 57% (13–85%) | 0.018 |
| mRS 0–2 at 3 months, n (%)§ | 222 (44%) | 142 (47%) | 80 (39%) | 0.055 |
| Safety outcome | ||||
| sICH, n (%) | 50 (9%) | 30 (9%) | 20 (9%) | 0.983 |
| Other serious complications,¶ n (%) | 29 (5%) | 21 (6%) | 8 (3%) | 0.157 |
Three-month mortality data were available in 510 patients. There were 73 cases with missing 3-month mortality data.
*Fulfilling criteria AHA Class I Level A recommendations.
†Not fulfilling criteria AHA Class I Level A recommendations.
‡Relative reduction in NIHSS score at discharge was calculated as follows: [(Admission NIHSS – Discharge NIHSS)×100]/Admission NIHSS.
§Three-month functional outcome was available in 510 patients. There were 73 cases with missing 3-month follow-up data.
¶Other complications including transient vasospasm, groin hematoma, vessel dissection and/or perforation.
AHA, American Heart Association; mRS, modified Rankin Scale; MT, mechanical thrombectomy; NIHSS, NIH Stroke Scale; sICH, symptomatic intracerebral hemorrhage.