Baseline characteristics
| Characteristics | All patients (n=58) | Isolated M2 or M3 (n=31) | LVO+M2 or M3, (n=27) | Difference (95% CI)* | p Value |
| Age (mean±SD, min, max), years | 68.8±12.4 (18, 94) | 68.6±13.3 (18, 90) | 69.0±11.4 (48, 94) | 0 (−6 to 6) | 0.9130 |
| Women (n/N (%)) | 33/58 (56.9%) | 18/31 (58.1%) | 15/27 (55.6%) | 2.5% (−23.4% to 28.0%) | 1.0000 |
| Isolated M2 or M3 occlusions (n/N (%)) | 31/58 (53.4%) | 31/31 (100%) | N/A | N/A | N/A |
| LVO in combination with M2 or M3 occlusions (n/N (%)) | 27/58 (46.6%) | N/A | 27/27 (100%) | N/A | N/A |
| Baseline NIHSS (median, IQR) | 15 (10–18) | 15 (9–19) | 15 (12–18) | 0 (−3, 3) | 0.9751 |
| Baseline ASPECTS score (median, IQR) | 9 (7–10) | 9 (8–10) | 8.5 (6–9.5) | 1 (0, 2) | 0.0601 |
| Baseline mRS score (mean±SD) | 4.4±0.7 (range 3–5) | 4.4±0.7 (range 3–5) | 4.4±0.7 (range 3–5) | 0 (0, 0) | 0.7611 |
| Baseline mTICI score of 0 (n/N (%)) | 58/58 (100%) | 31/31 (100%) | 27/27 (100%) | 0%, N/A | 1.0000 |
| Time from symptom onset to door (median, IQR), min | 60 (50–75) | 60 (50–75) | 60 (50–75) | 0 (−10, 10) | 0.9562 |
| IV thrombolysis (n/N (%)) | 53/58 (91.4%) | 29/31 (93.5%) | 24/27 (88.9%) | 4.7% (−20.8% to 29.9%) | 0.6557 |
| Time from symptom onset to IV thrombolysis (median, IQR), min | 82.5 (70–100) | 80 (70–100) | 85 (75–90) | 0 (−10, 10) | 0.7719 |
*Wilcoxon rank sum or Fisher’s exact test for difference between isolated M2 or M3 and LVO + M2 or M3 groups. Hodges-Lehmann estimate and CI was computed for results of Wilcoxon rank sum test. Exact estimate and Clopper-Pearson CI was computed for results of Fisher’s exact test.
ASPECTS, Alberta Stroke Program Early CT Score; LVO, Large vessel occlusion (internal carotid artery (ICA), ICA terminus or M1 middle cerebral artery); mRS, modified Rankin Scale; mTICI, modified Thrombolysis In Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale.