Definition of the term large vessel occlusion in recent literature evaluating endovascular therapy
| Study | Year of publication | Only anterior circulation | Definition of large vessel occlusion in publication |
| MR CLEAN1 | 2015 | Yes | Occlusion of the distal intracranial internal carotid artery (ICA), middle cerebral artery (MCA, M1 or M2 segments), or anterior cerebral artery (A1 or A2 segments) |
| EXTEND-IA2 | 2015 | Yes | Occlusion of the ICA or of the first or second segment of the MCA |
| SWIFT PRIME5 | 2015 | Yes | Occlusion of the intracranial ICA, the first segment of the MCA |
| ESCAPE3 | 2015 | Yes | Occlusion of the MCA trunk and its immediate branches, with or without intracranial occlusion of the ICA |
| REVASCAT4 | 2015 | Yes | Occlusion of the intracranial ICA (distal ICA or T occlusions), M1 or tandem occlusions |
| THRACE6 | 2016 | No | Occlusion of the intracranial ICA, the M1 segment of the MCA, or the superior third of the basilar artery |
| DAWN7 | 2017 | Yes | Occlusion of the intracranial ICA, first segment of the MCA, or both |
| DEFUSE 323 | 2018 | Yes | Occlusion of the ICA or MCA-M1 segment |