Baseline and procedural characteristics of the TRACK Registry compared with TREVO2 and TRACK AHA/ASA and non-AHA/ASA sub-cohorts
| TRACK (n=629) N (%) | TREVO2 (n=88) N (%) | p Value TRACK versus TREVO2 | TRACK-AHA/ASA (n=157) N (%) | TRACK-non-AHA/ASA (n=450) N (%) | p Value AHA/ASA versus non-AHA/ASA | |
| Demographics | ||||||
| Age (years), mean (SD) | 66.1 (14.8) | 67.4 (13.9) | 0.24 | 64.9 (15.5) | 66.5 (14.5) | 0.24 |
| Age >80 | 114 (18.1) | NA | NA | 27 (17.2) | 85 (18.9) | 0.72 |
| Gender (female) | 305 (48.3) | 48 (55) | 0.3 | 71 (45.2) | 220 (48.9) | 0.46 |
| Race (white) | 424 (68.1) | NA | NA | 101 (64.3) | 305 (69.0) | 0.09 |
| Vascular risk factors | ||||||
| Hypertension | 473 (75.0) | 67 (76) | 0.04 | 124 (79.0) | 335 (74.4) | 0.28 |
| Atrial fibrillation | 247 (39.2) | 42 (48) | 0.13 | 56 (35.7) | 184 (41.0) | 0.26 |
| Diabetes mellitus | 161 (25.5) | 33 (38) | 0.02 | 41 (26.1) | 117 (26.0) | 1.00 |
| Hyperlipidemia | 314 (49.8) | 55 (63) | 0.03 | 76 (48.4) | 229 (50.2) | 0.64 |
| Smoking history | 154 (24.5) | 37 (42) | 0.001 | 40 (25.5) | 112 (25.0) | 0.92 |
| Coronary artery disease | 146 (29.4) | 29 (33) | 0.1 | 35 (28.2) | 104 (29.6) | 0.82 |
| Clinical presentation | ||||||
| Baseline mRS (median) (min, max) | 0 (0,5) | 0 (0,1) | 0 (0,1) | 0 (0,5) | ||
| Initial NIHSS, mean (SD) | 17.4 (6.7) | 18.3 (5.3) | 0.04 | 18.0 (5.8) | 17.2 (6.9) | 0.19 |
| Occlusion site | ||||||
| All MCA segments | 434 (68.9) | 67 (76) | 0.002 | 118 (75.2) | 298 (66.4) | 0.06 |
| M1 | 344 (54.6) | 53 (60) | 0.03 | 118 (75.2) | 209 (70.1) | 0.0001 |
| M2 | 84 (13.3) | 14 (16) | 0.5 | 0 (0) | 83 (27.9) | 0.0001 |
| M3 | 6 (1.0) | 0 (0) | 0.2 | 0 (0) | 6 (2.0) | 0.34 |
| ICA | 100 (15.9) | 14 (16) | 1.0 | 39 (24.8) | 55 (12.3) | 0.0003 |
| Vertebrobasilar circulation | 84 (12.7) | 7 (8) | 0.2 | 0 (0) | 84 (18.7) | 0.0001 |
| Anterior circulation | 546 (86.7) | 81 (92) | 0.2 | 157(100) | 365 (81.3) | 0.0001 |
| Initial systolic BP, mean (SD) | 144.9 (26.6) | NA | NA | 145.9 (28.1) | 144.7 (26.2) | 0.68 |
| Initial diastolic BP, mean (SD) | 78.2 (19.2) | NA | NA | 78.6 (20.9) | 78.1 (18.6) | 0.63 |
| IV tPA | 321 (51.2) | 51 (58) | 0.22 | 157 (100) | 164 (34.9) | 0.0001 |
| Hospital transfer | 315 (50.0) | NA | NA | 62 (39.5) | 237 (52.8) | 0.005 |
| Procedural factors | ||||||
| Time from onset to puncture (min), mean (SD) | 363.1 (264.5) | 276 (90) | 0.00 | 217.5 (67.8) | 413.8 (287.7) | <0.0001 |
| General anesthesia | 394 (62.4) | 72 (82) | 0.004 | 89 (56.7) | 284 (63.1) | 0.2 |
| Regional aspiration | 142 (22.6) | NA | NA | 44 (30.3) | 98 (23.6) | 0.12 |
| IA tPA | 130 (20.7) | NA | NA | 46 (29.3) | 83 (18.5) | 0.006 |
| Balloon guide catheter | 298 (47.3) | NA | NA | 84 (53.5) | 206 (45.9) | 0.08 |
Bold type indicates statistical significance.
AHA, American Heart Association; ASA, American Stroke Association; ICA, internal carotid artery; mRS, modified Rankin Scale; MCA, middle cerebral artery; NIHSS, National Institutes of Health Stroke Scale; tPA, tissue plasminogen activator.