Clinical and angiographic outcomes of the TRACK Registry versus TREVO2, AHA/ASA and non-AHA/ASA sub-cohorts
| TRACK (n=629) N (%) | TREVO2 (n=88) N(%) | p Value TRACK versus TREVO2 | *TRACK-AHA/ASA (n=157) N (%) | *TRACK-non-AHA/ASA (n=450) N (%) | *p Value AHA/ASA versus non-AHA/ASA | |
| Clinical outcome | ||||||
| mRS ≤2 at 90 days | 277 (47.9) | 34 (40) | 0.2 | 75 (51.4) | 193 (46.7) Anterior circulation only: 158/333 (47.5%) | 0.34 0.49 |
| NIHSS at discharge, mean (SD) | 17.4 (6.7) | NA | NA | 11.3 (11.3) | 11.3 (11.1) | 1.00 |
| NIHSS at 90 days, mean (SD) | 18.1 (18.7) | NA | NA | 13.7 (16.6) | 19.9 (19.3) Anterior circulation only: 18.9 (19) | 0.04 0.1 |
| Mortality at 90 days | 106 (19.8) | 29 (33) | 0.01 | 19 (14.1) | 85 (22.2) Anterior circulation only: 59 (19.3) | 0.05 0.22 |
| sICH | 44 (7.1) | 4 (4.5) | 0.4 | 8 (5.2) | 35 (8.0) | 0.28 |
| Angiographic outcomes | ||||||
| TIMI ≥2 | 564 (89.7) | NA | NA | 141 (89.8) | 400 (89.6) | 1.0 |
| TICI ≥2a | 584 (92.8) | 73 (85) | 0.0004 | 146 (93.0) | 415 (92.9) | 1.0 |
| TICI ≥2b | 505 (80.3) | 60 (68)* | 0.005 | 128 (81.5) | 360 (80.4) | 0.81 |
| TICI 2a | 79 (12.6) | 19 (22)* | 0.004 | 19 (12.1) | 60 (12.7) | 0.89 |
| TICI 2b | 225 (35.8) | 48 (54)* | 0.001 | 45 (28.7) | 180 (38.1) | 0.03 |
| TICI 3 | 280 (44.5) | 12 (14)* | <0.05 | 82 (52.2) | 198 (41.9) | 0.03 |
| Distal embolization | 112 (23.0) | NA | NA | 24 (19.4) | 81 (23.7) | 0.38 |
| Embolization into new territory | 20 (4.5) | NA | NA | 10 (8.3) | 9 (2.9) | 0.042 |
| No of passes, mean (SD) | 1.9 (1.2) | 2.4 (1.4) | 0.002 | 2.0 (1.1) | 1.9 (1.2) | 0.40 |
| 1 | 272 (45.6) | NA | NA | 61 (41.2) | 201 (47.1) | 0.22 |
| 2 | 167 (28.2) | NA | NA | 44 (29.7) | 123 (27.5) | 0.92 |
| 3 | 112 (18.8) | NA | NA | 34 (23.0) | 78 (17.4) | 0.23 |
| >3 | 45 (7.5) | NA | NA | 6 (4.1) | 36 (8.0) | 0.10 |
| Use of rescue therapy | 133 (21.5) | 16 (18) | 0.48 | 35 (22.9) | 93 (21.0) | 0.65 |
| Type of rescue therapy (65/133) | ||||||
| Solitaire | 29 (44.6) | |||||
| IA-tPA | 28 (43.1) | |||||
| Aspiration | 41 (63.1) | |||||
| Intracranial angioplasty | 15 (23.1) | |||||
| Fluoroscopic time (min) | 32.3 (22.9) | NA | NA | 31.9 (21.2) | 32.8 (23.8) | 0.35 |
| Time of puncture to revascularization or end of procedure (min), mean (SD) | 78.8 (49.6) | NA | NA | 77.1 (46.8) | 79.2 (48.9) | 0.64 |
*Core laboratory adjudicated.
Bold type indicates statistical significance.
AHA, American Heart Association; ASA, American Stroke Association, mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; sICH, symptomatic intracranial hemorrhage; TICI, Thrombolysis In Cerebral Infarction; tPA, tissue plasminogen activator.