Univariable and multivariable logistic regression analyses of the associations of antiplatelet pretreatment and other baseline characteristics with the probability of complete reperfusion (defined as Modified Thrombolysis in Cerebral Infarction grades 2b or 3) following mechanical thrombectomy in patients with emergent large vessel occlusion
| Univariable logistic regression analysis | Multivariable logistic regression analysis | |||
| Variable | Odds ratio (95% CI) | P value* | Odds ratio (95% CI) | P value |
| Age | 1.01 (0.99 to 1.03) | 0.554 | – | – |
| Male sex | 0.94 (0.53 to 1.67) | 0.847 | – | – |
| African-American race | 1.02 (0.58 to 1.82) | 0.935 | – | – |
| NIHSS score at admission (per 1-point increase) | 1.00 (0.96 to 1.04) | 0.960 | – | – |
| ASPECTS at baseline (per 1-point increase) | 1.30 (1.06 to 1.60) | 0.011 | 1.26 (0.99 to 1.6) | 0.062 |
| Occlusion in posterior circulation | 0.82 (0.40 to 1.68) | 0.590 | – | – |
| Tandem occlusion† | 1.74 (0.71 to 4.27) | 0.228 | – | – |
| Proximal occlusion‡ | 0.92 (0.52 to 1.64) | 0.775 | – | – |
| Good collateral score | 1.95 (1.02 to 3.72) | 0.042 | 1.86 (0.96 to 3.62) | 0.067 |
| Intracranial atherosclerotic disease | 0.84 (0.46 to 1.53) | 0.560 | – | – |
| Hypertension | 0.83 (0.42 to 1.65) | 0.604 | – | – |
| Diabetes mellitus | 0.96 (0.53 to 1.73) | 0.893 | – | – |
| Hyperlipidemia | 1.13 (0.63 to 2.04) | 0.672 | – | – |
| Atrial fibrillation | 0.79 (0.41 to 1.50) | 0.469 | – | – |
| Congestive heart failure | 1.33 (0.60 to 2.95) | 0.477 | – | – |
| Smoking | 1.16 (0.62 to 2.20) | 0.637 | – | – |
| Prior antiplatelet use | 2.31 (1.19 to 4.47) | 0.013 | 2.18 (1.01 to 4.73) | 0.048 |
| Intravenous thrombolysis | 1.42 (0.79 to 2.56) | 0.237 | – | – |
| Onset to arterial puncture time (per 10 min increase) | 1.00 (0.98 to 1.01) | 0.902 | – | – |
| Serum glucose at admission (per 10 mg/dL increase) | 0.98 (0.95 to 1.02) | 0.371 | – | – |
| Systolic blood pressure at admission (per 10 mmHg increase) | 1.07 (0.97 to 1.19) | 0.163 | – | – |
| Diastolic blood pressure at admission (per 10 mmHg increase) | 1.04 (0.91 to 1.19) | 0.569 | – | – |
*Cut-off of P<0.1 was used for selection of candidate variables for inclusion in multivariable logistic regression models.
†Simultaneous presence of both intracranial and extracranial arterial occlusions in the distribution of acute ischemic stroke.
‡Internal carotid artery or basilar artery occlusion in the anterior and posterior circulation, respectively.
ASPECTS, Alberta Stroke Program Early CT score; NIHSS, National Institutes of Health Stroke Scale.