Table 1

Schedule of events

ActivityBaselineRandomization/
procedure
24 hours post-randomization7 days post-randomization or discharge30 days post-randomization90 days post-randomizationNeurological deteriorationAny additional FU (if needed)Study closure
Evaluation of criteriaX
Informed consentX
RandomizationX
Past medical historyX
Clinical evaluationXXXXXXX
Modified Rankin Scale*XXXXX†X
NIHSS*XXXX†XX
Stroke Impact ScaleX
CT/CTA or MRI/MRA‡XXX
Angiogram, TICI scoresX
Mechanical thrombectomy procedureX
Concomitant medicationsXXXXXX
Adverse event assessmentXXXXXXXX
  • *Must be completed by an unbiased healthcare provider.

  • †Must be completed by a blinded stroke study team member. If possible, it is preferred for these assessments to be completed also by a blinded team member at the other time points.

  • ‡CT/CTA or MRI/MRA are required at baseline and 24 hours post-randomization, and any time there is a neurological deterioration (a change in NIHSS of 4 points or more) or hemorrhage.

  • CTA, CT angiography; FU, follow-up; MRA, MR angiography; NIHSS, National Institutes of Health Stroke Scale; TICI, Thrombolysis in Cerebral Infarction.