Table 4

Antiplatelet regimen employed in each study

AuthorAntiaggregatePostprocedural antiaggregate
Sauvageau et al25
  • IA or IV eptifibatide immediately prior to stenting (180 μg/kg) without maintenance infusion

  • 325–650 mg aspirin and 300–600 mg clopidogrel loading immediately after procedure

  • 325 mg aspirin and 75 mg clopidogrel for 6 weeks

  • 325 mg aspirin daily indefinitely

Baek et al26
  • All stented patients given IA bolus glycoprotein IIb/IIIa bolus (Reopro 5–10 mg) then maintained on infusion for 24 hours

  • Dual antiplatelet medication for at least 3 months

Baracchini et al27
  • All patient who had not already received IA tirofiban in an attempt to recanalize occluded vessel were given IA bolus (25 μg/kg over 3 min) to maintain stent patency

  • All patients maintained on IV tirofiban 12 hour infusion (0.1 μg/kg) post-stent insertion

  • Double antiplatelet medication for 3 months

Delgado Acosta et al28
  • Aspirin 300mg+300 mg clopidogrel and/or glycoprotein IIb/IIIa (0.1 mg/kg abciximab)

  • 100 mg aspirin and 75 mg clopidogrel for 1 year, then 100 mg aspirin life long

Chang et al29Mixed strategies:
  • Loading tirofiban 0.3–1.0 mg or Reopro 5–10 mg followed by IV infusion of the same for 6–12 hours

  • In 40 patients either pre- or post-stent:

    • Loading aspirin 100–500 mg and Plavix 300 mg or

    • Monotherapy just after stenting with Plavix 75–300 mg

  • In 8 patients antiplatelets withheld

  • In 40 of 48 patients, aspirin, clopidogrel or both

Nappini et al30
  • After stent deployed, IV tirofiban 25 μg/kg over 3 min, followed by 12 hour 0.1  μg/kg infusion

  • Postprocedure CT to rule out intracranial hemorrhage, if none 300 aspirin+300 mg clopidogrel loading then 100 mg aspirin/75 mg clopidogrel for 3 months, then lifelong single antiaggregate

Zhou, et al31
  • In patients who received stent deployment, tirofiban was administered IV with 8.0 g/kg bolus over a period of 3 min immediately before stent deployment, followed by a maintenance dose of 0.10 g/kg/min up to 24 hours after procedure.

  • 2 hours before cessation of infusion, loading clopidogrel (300 mg) and aspirin (300 mg)+half dose infusion

  • 75 mg clopidogrel and 100 mg aspirin daily for 3–6 month

Ahmed et al32
  • Full loading dose of IA abciximab (0.25 mg/kg). Immediately after the procedure, the patients received 325 mg of aspirin, either orally or rectally

  • If the postoperative CT did not show evidence of intracranial hemorrhage, patients loaded with clopidogrel 600 mg, followed by daily aspirin and clopidogrel

  • IA, intra-arterial; IV, intravenous.