Table 1

Summary of methodological characteristics of included studies

StudyYearStudy typeStudy periodNumber of patients (n)ASPECTS cut-offClinical measureImaging for ASPECTS
Goyal et al6 (ESCAPE)2015Randomized controlled trialDec 2014– present3166–7, 8–1090-day mRS ≤2Non-contrast CT
Saver et al7 (SWIFT-PRIME)2015Randomized controlled trialDec 2012–present1966–7, 8–1090-day mRS ≤2Non-contrast CT or MRI DWI
Jovin et al8 (REVASCAT)2015Randomized controlled trialNov 2012– Dec 2014206≥7 (score <7 on non-contrast CT or <6 on MRI DWI excluded)90-day mRS ≤2Non-contrast CT or MRI DWI
Yoo et al23 (MR CLEAN)2016Retrospective cohort studyDec 2010– June 20144960–4, 5–7, 8–10mRS ≤2 at discharge–
Bracard et al (THRACE)52016Randomized controlled trialJune 2010- Feb 20154140–4, 5–7, 8–1090-day mRS ≤2–
Wasser et al252016Retrospective cohort studyJan 2008–Dec 20147340–5, 6–7, 8–10mRS ≤2 at dischargeNon-contrast CT
Kim et al222016Retrospective cohort studyDec 2010- Dec 20131714–6, 7–1090-day mRS ≤2MRI (DWI)
Haussen et al262016Retrospective cohort studySept 2010– Sept 2015332<690-day mRS ≤2Non-contrast CT
Logan et al152017Retrospective cohort study2014–2016355≤690-day mRS ≤2Non contrast CT
Hungerford et al202017Retrospective cohort studyDec 2012– May 2015154≤690-day mRS ≤2Non-contrast CT
Desilles et al212017Retrospective cohort studyJan 2012–Aug 2015218≤690-day mRS ≤2MRI (DWI)
Li et al242017Retrospective cohort studyJan 2014– June 2016415 vs 690-day mRS ≤2Non-contrast CT
Mourand et al192018Retrospective cohort studyJan 2009– Dec 2014108≤590-day mRS ≤2MRI (DWI)

  • *mRS, modified Rankin Score; CT, computed tomography; MRI, magnetic resonance imaging; DWI, diffusion-weighted imaging.