Baseline characteristics, interventional procedure data, and outcomes in patients treated 6–24 hours after last seen well
| Wake-up stroke (n=34) | Late presenting stroke (n=29) | P value | |
| Age, years (min–max) | 75.5 (64–83.5) | 73 (54–80) | 0.127 |
| Female | 20 (58.8) | 14 (48.3) | 0.402 |
| Pre-stroke mRS <2 | 32 (94.1) | 26 (89.7) | 0.654 |
| Vascular risk factors | |||
| Arterial hypertension | 26 (76.5) | 18 (62.1) | 0.214 |
| Diabetes | 9 (26.5) | 11 (37.9) | 0.33 |
| Dyslipidemia | 23 (67.6) | 16 (55.2) | 0.31 |
| Current smoking | 7 (20.6) | 6 (20.7) | 0.992 |
| Ischemic heart disease | 7 (20.6) | 5 (17.2) | 0.736 |
| Glucose at admission, mg/dL | 131 (104–154) | 130.5 (109–207) | 0.457 |
| Admission NIHSS | 16 (14–18) | 15 (9–20) | 0.516 |
| Admission ASPECTS | 8 (7–9) | 8 (7–9) | 0.822 |
| Occlusion site | |||
| Intracranial ICA | 6 (17.6) | 9 (31.0) | 0.214 |
| MCA M1 segment | 21 (61.8) | 14 (48.3) | 0.283 |
| MCA M2 segment | 7 (20.6) | 6 (20.7) | 0.992 |
| Tandem occlusion | 9 (26.5) | 7 (24.1) | 0.832 |
| Stroke etiology | |||
| Cardioembolism | 20 (58.8) | 10 (34.5) | 0.054 |
| Large artery atherosclerosis | 7 (20.6) | 7 (24.1) | 0.736 |
| Undetermined etiology | 7 (20.6) | 7 (24.1) | 0.736 |
| Other etiology | 0 | 5 (17.3) | 0.017 |
| Intravenous thrombolysis | 5 (14.7) | 17 (58.6) | <0.001 |
| LSW-groin puncture time (min) | 817.5 (676–1005) | 462 (412–516) | <0.001 |
| LSW-recanalization time (min) | 997 (822–1275) | 534 (470–585) | <0.001 |
| Favorable collateral status* | 12 (52.2) | 14 (66.7) | 0.329 |
| Number of passages | 2 (1–3) | 1 (1–3) | 0.474 |
| Successful recanalization (mTICI ≥2b) | 33 (97.1) | 27 (93.1) | 0.59 |
| NIHSS at 24 hours | 8 (3–13) | 7 (3–15) | 0.825 |
| mRS ≤2 at 3 months | 21 (61.8) | 20 (69.0) | 0.55 |
| Mortality at 3 months | 4 (11.8) | 1 (3.4) | 0.363 |
| Symptomatic ICH | 1 (2.9) | 1 (3.4) | 1 |
| Peri-procedural complications† | 3 (8.8) | 1 (3.4) | 0.618 |
Continuous or ordinal variables are expressed as n (%) or median (IQR).
*Collateral status available for 44 patients.
†Peri-procedural complications include cases of arterial perforation or dissection, access site complications, and distal embolization to a new territory.
ASPECTS, Alberta Stroke Programme Early CT Score; ICA, internal carotid artery; ICH, intracranial hemorrhage; LPS, late-presenting strokes; LSW, last seen well; MCA, middle cerebral artery; mRS, modified Rankin Scale; mTICI, modified TICI; NIHSS, National Institutes of Health Stroke Scale; WUS, wake-up stroke.