Demographics and baseline characteristics stratified by leukoaraiosis severity
| All patients (n=251) | Absent to moderate LA (n=213) | Severe LA (n=38) | P values | |
| Age, mean (SD),y | 64.4 (11.8) | 62.6 (11.3) | 74.6 (9.2) | <0.001 |
| Male, n (%) | 156 (62.2) | 140 (65.7) | 16 (42.1) | 0.006 |
| Smoking, n (%) | 71 (28.3) | 64 (30.0) | 7 (18.4) | 0.143 |
| Drinking, n (%) | 36 (14.3) | 32 (15.0) | 4 (10.5) | 0.466 |
| LDL*, mean (SD), mmol/L | 2.57 (0.88) | 2.56 (0.89) | 2.60 (0.86) | 0.855 |
| Glucose†, median (IQR), mmol/L | 6.80 (5.70–8.53) | 6.70 (5.59–8.30) | 7.89 (6.47–10.56) | 0.005 |
| Medical history | ||||
| CHD, n (%) | 50 (19.9) | 35 (16.4) | 15 (39.5) | 0.001 |
| Atrial fibrillation, n (%) | 115 (45.8) | 92 (43.2) | 23 (60.5) | 0.048 |
| Hypertension, n (%) | 142 (56.6) | 112 (52.6) | 30 (78.9) | 0.003 |
| Diabetes mellitus, n (%) | 47 (18.7) | 35 (16.4) | 12 (31.6) | 0.027 |
| Ischemic stroke, n (%) | 32 (12.7) | 23 (10.8) | 9 (23.7) | 0.028 |
| Clinical characteristics | ||||
| Baseline SBP, median (IQR), mm Hg | 140 (128–159) | 140 (127–155) | 149 (130–160) | 0.122 |
| Baseline NIHSS score, median (IQR) | 16 (12–20) | 15 (12–20) | 20 (15–25) | <0.001 |
| Stroke cause, n (%) | 0.930 | |||
| LAA | 98 (39) | 83 (39.0) | 15 (39.5) | |
| Cardioembolic | 129 (51.4) | 109 (51.2) | 20 (52.6) | |
| Undetermined or others | 24 (9.6) | 21 (9.9) | 3 (7.9) | |
| Procedure process | ||||
| IVT, n (%) | 82 (32.7) | 77 (36.2) | 5 (13.2) | 0.005 |
| ASITN/SIR≥2, n (%) | 138 (55.0) | 123 (57.7) | 15 (39.5) | 0.037 |
| OTR, median (IQR), min | 361 (289–441) | 363 (294–442) | 356(278-442) | 0.486 |
| mTICI 2b/3, n (%) | 192 (76.5) | 163 (76.5) | 29 (76.3) | 0.978 |
ASITN/SIR indicates American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology; CHD, coronary heart diseases; IVT, intravenous thrombolysis; LA, leukoaraiosis; LAA, large-artery atherosclerosis; LDL, low-density lipoprotein; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; OTR, symptoms onset to recanalization time; SBP, systolic blood pressure.
*Missing data in 63 patients.
†Missing data in 17 patients.