Baseline and procedural characteristics
| Characteristic | Patients (N) |
| Age, years | 71.3±12.4 (204) (mean±SD) 74/65–80 (median/IQR) |
| Female | 61.8% (126/204) |
| Baseline NIHSS | 15.4±5.8 (204) (mean±SD) 16/11–20 (median/IQR) |
| < 16 | 46.6 % (95/204) |
| 16 – 20 | 32.8 % (67/204) |
| > 20 | 20.6 % (42/204) |
| CT ASPECTS*: per site assessment | 8.7±1.2 (173) (mean±SD) 9/8–10 (median/IQR) |
| MR DWI ASPECTS: per site assessment | 7.4±1.5 (30) (mean±SD) 8/6–8 (median/IQR) |
| IV rt-PA administered prior to procedure | 61.8% (126/204) |
| Time from symptom onset to hospital admission (min) | 115.3±78.6 (204) (mean±SD) 97.0/58.5–154.5 (median/IQR) |
| Site of vessel occlusion | |
| Internal carotid artery/carotid T | 21.1% (43/204) |
| Middle cerebral artery | 78.9 % (161/204) |
| First segment (M1) | 60.8% (124/204) |
| Second segment (M2) | 18.1% (37/204) |
| Procedural information | |
| Penumbra ACE Catheters, (% n/N) | All patients (n=204) |
| Frontline device | |
| ACE68 | 65.7 % (134/204) |
| ACE64 | 32.8 % (67/204) |
| Other Penumbra catheters: 3MAX, 5MAX, ACE 60 | 1.5% (3/204)† |
| Frontline ACE68/64 catheter passes | 1.6±0.9 (201) (mean±SD (N)) 1/1–2 (median/IQR) |
| Additional mechanical intervention (% n/N)‡ | ACE 68/64 PATIENTS n=201 |
| Stent retriever after Penumbra System, total | 20.9 % (42/201) |
| Target vessel/remaining clot | 13.4 % (27/201) |
| Distal vasculature | 9% (18/201) |
| Stent for proximal stenosis or dissection | 2% (4/201) |
| Balloon angioplasty for proximal stenosis | 2% (4/201) |
| Catheter from other manufacturer | 1% (2/201) |
Data are % (n/N) or mean ±SD (N) (median) (IQR). ASPECTS, Alberta Stroke Program Early CT Score; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; mRS, modified Rankin Scale.
*One patient with ASPECTS score not available due to a previous stroke. Principal Investigator confirmed the inclusion of the patient.
†Three patients were treated with ACE60, 3MAX, or 5MAX, admitted under protocol version B.
‡Patients may have more than one additional mechanical intervention.