Summary of findings for PICO 3. Question: PICO 3: IVT+MT compared with MT alone for LVO-related acute ischaemic stroke
| Certainty assessment | № of patients | Effect | Quality of evidence | Importance | ||||||||
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | IVT+MT | MT alone | Relative (95% CI) | Absolute (95% CI) | ||
| mRS score 0–2 | ||||||||||||
| 13 | Observational studies | Very serious* | Not serious | Serious† | Not serious | None | 861/1769 (48.7%) | 520/1174 (44.3%) |
OR=1.27
(1.05 to 1.55) |
60 more per 1 000
(from 12 more to 109 more) | ⨁◯◯◯ VERY LOW | CRITICAL |
*Selection bias; confounding by indication.
†Potential differences in populations.
CI, confidence interval; IVT, intavenous thrombolysis; LVO, large vessel occlusion; MT, mechanical thrombectomy; OR, odds ratio.