Table 5

Summary of findings for PICO 3. Question: PICO 3: IVT+MT compared with MT alone for LVO-related acute ischaemic stroke

Certainty assessment№ of patientsEffectQuality of evidenceImportance
№ of studiesStudy designRisk of biasInconsistencyIndirectnessImprecisionOther considerationsIVT+MTMT aloneRelative
(95% CI)
Absolute
(95% CI)
mRS score 0–2
 13Observational studiesVery serious*Not seriousSerious†Not seriousNone861/1769 (48.7%)520/1174 (44.3%) OR=1.27
(1.05 to 1.55)
60 more per 1 000
(from 12 more to 109 more)
 ⨁◯◯◯
 VERY LOW
CRITICAL
  • *Selection bias; confounding by indication.

  • †Potential differences in populations.

  • CI, confidence interval; IVT, intavenous thrombolysis; LVO, large vessel occlusion; MT, mechanical thrombectomy; OR, odds ratio.