Summary of findings table for PICO 6
| Certainty assessment | № of patients | Effect | Quality of evidence | Importance | ||||||||
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | MT+BMM | BMM alone | Relative (95% CI) | Absolute (95% CI) | ||
| 0–6 hour time window: mRS score 0–2 | ||||||||||||
| 4 | Randomized trials | Not serious | Not serious | Not serious | Serious* | None |
RR=2.09
(1.03 to 4.25) | ⨁⨁⨁◯ MODERATE | CRITICAL | |||
| 6–24 hour time window: mRS score 0–2 | ||||||||||||
| 2 | Randomized trials | Not serious | Not serious | Not serious | Very serious*† | None | 16/47 (34.0%) | 5/53 (9.4%) |
RR=3.53
(0.87 to 14.29) OR=4.87 (1.15 to 20.71) |
239 more per 1000
(from 12 fewer to 1000 more) | ⨁⨁◯◯ LOW | CRITICAL |
*Clinical action (MT or no MT) would differ if the upper versus the lower boundary of the CI represented the truth.
†The absolute number of patients over 80 years in DAWN and DEFUSE-3 was small (n=100) and the number of qualifying events (moved from dependence to independence) was much lower still.
BMM, best medical management; CI, confidence interval; MT, mechanical thrombectomy; RR, risk ratio