Table 6

Summary of findings table for PICO 6

Certainty assessment№ of patientsEffectQuality of evidenceImportance
№ of studiesStudy designRisk of biasInconsistencyIndirectnessImprecisionOther considerationsMT+BMMBMM aloneRelative
(95% CI)
(95% CI)
0–6 hour time window: mRS score 0–2
 4Randomized trialsNot seriousNot seriousNot seriousSerious*None RR=2.09
(1.03 to 4.25)
6–24 hour time window: mRS score 0–2
 2Randomized trialsNot seriousNot seriousNot seriousVery serious*†None16/47 (34.0%)5/53 (9.4%) RR=3.53
(0.87 to 14.29)
OR=4.87 (1.15 to 20.71)
239 more per 1000
(from 12 fewer to 1000 more)
  • *Clinical action (MT or no MT) would differ if the upper versus the lower boundary of the CI represented the truth.

  • †The absolute number of patients over 80 years in DAWN and DEFUSE-3 was small (n=100) and the number of qualifying events (moved from dependence to independence) was much lower still.

  • BMM, best medical management; CI, confidence interval; MT, mechanical thrombectomy; RR, risk ratio