Treatment details, angiographic and clinical outcomes
| 0-6 Hours (N=559) | 6-16 Hours (N=248) | 16-24 Hours (N=20) | >24 Hours (N=3) | P values | |
| Treatment details | |||||
| Symptom onset to groin puncture (min), mean SD, median [IQR] | 224±73 218 [173-277] | 533±151 480 [412-630] | 1123±163 1114 [1023-1215] | 1662 ±2234 1535 [1530-1920] | <0.0001 |
| Door to groin puncture (min), mean±SD, median [IQR] | 123±7 112 [72-162] | 161±11 129.5 [82-222] | 139±49 92 [80-245] | 63±84 63 [63-63] | 0.03 |
| Procedure duration (min), mean ±SD, median [IQR] | 98±54 86 [57-120] | 94 ±64 88 [54-114] | 67±46 44 [38-108] | 151±4. 151 [148-154] | 0.03 |
| Fluoroscopy time (min), mean±SD, median [IQR] | 31±25 24 [15-41] | 33±22 26 [17-45] | 46±31 43 [19-75] | 26±28.0 26 [7-46] | 0.2 |
| Number of passes with Trevo, mean±SD, median [IQR] | 1.9±1 2 [1-3] | 2.1±1.3 2 [1-3] | 1.7±1.2 1 [1-2] | 2.7±1.5 2 [1-4] | 0.11 |
| BGC use, n (%) | 262/550 (47.6%) | 137/242 (56.6%) | 10/20 (50%) | 1/3 (33.3%) | 0.12 |
| Trevo+aspiration, n (%) | 124/520 (23.8%) | 40/233 (17.2%) | 5/19 (26.3%) | 0 | 0.15 |
| General anesthesia, n (%) | 324/521 (62.2%) | 135/229 (59%) | 9/19 (47.4%) | 1/2 (50%) | 0.52 |
| Use of rescue treatment, n (%) | 126/552 (22.8%) | 54/245 (22%) | 5/20 (25%) | 2/3 (66.7%) | 0.33 |
| Intra-arterial tPA use, n (%) | 150/557 (26.9) | 48/248 (19.4%) | 4/20 (20%) | 0 | 0.09 |
| Time from puncture to recanalization (min), mean±SD, median [IQR] | 75±62 58[35-93] | 76±55 65[37-102] | 95±70 69[46-136] | 72± 70 72[22-121] | 0.62 |
| Radiographic outcome | |||||
| ≥TICI 2b, n (%) | 444/559 (79.4%) | 180/248 (72.6%) | 17/20 (85%) | 1/3 (33.3%) | 0.04 |
| ≥TICI 2a, n (%) | 517/559 (92.5%) | 220/248 (88.7%) | 18/20 (90%) | 2/3 (66.7%) | 0.15 |
| Distal embolization, n (%) | 96/472 (20.3%) | 49/213 (23%) | 2/14 (14.3%) | 1/2 (50%) | 0.57 |
| Embolization of new territory, n (%) | 28/444 (6.3%) | 7/207 (3.4%) | 0 | 0 | 0.33 |
| Clinical outcome | |||||
| mRS≤2 at 90 days, n (%) | 234/486 (48.1%) | 96/208 (46.2%) | 7/18 (38.9%) | 1/3 (33.3%) | 0.8 |
| Mortality, n (%) | 100/486 (20.6%) | 45/208 (21.6%) | 6/18 (33.3%) | 1/3 (33.3%) | 0.6 |
| Symptomatic ICH, n (%) | 44/551 (8%) | 27/247 (10.9%) | 1/20 (5%) | 0 | 0.5 |
BGC, balloon guide catheter; ICH, intracerebral hemorrhage; mRS, modified Rankin scale; TICI, Thrombolysis in Cerebral Infarction; tPA, tissue plasminogen activator.