Table 2

Comparison of main angiographic and clinical outcomes according to susceptibility vessel sign (SVS) on MRI

Outcomes	SVS– (n=52)	SVS+ (n=165)	Effect size	Study-adjusted		Fully adjusted
Outcomes	SVS– (n=52)	SVS+ (n=165)	Effect size	Values (95% CI)	P Values	Values (95% CI)*	P Values*
Angiographic outcomes
Reperfusion at end of procedure
mTICI 3	20/52 (38.5)	53/165 (32.1)	OR	0.95 (0.48 to 1.86)	0.88	0.96 (0.45 to 2.06)	0.92
mTICI 2b/3	42/52 (80.8)	133/165 (80.6)	OR	1.34 (0.59 to 3.17)	0.47	1.31 (0.51 to 3.38)	0.58
Clinical outcomes
mRS score at 3 months	3 (1 to 5)†	2 (1 to 4)†	Common OR‡	2.26 (1.27 to 4.03)	0.005	2.75 (1.44 to 5.26)	0.002
Favorable outcome at 3 months	23/52 (44.2)	98/165 (59.4)	OR	2.03 (1.06 to 3.91)	0.034	2.76 (1.18 to 6.45)	0.019
Change in NIHSS at 24 hours§	−3.1 (−5.6 to −0.6)¶	−6.3 (−7.7 to −5.0)¶	Mean difference**	−3.20 (−6.04 to −0.35)	0.028	−2.59 (−5.66 to 0.48)	0.098
Intracranial hemorrhage at 24 hours	21/51 (41.2)	67/164 (40.9)	OR	0.99 (0.51 to 1.92)	0.98	0.98 (0.47 to 2.05)	0.96

Values expressed as the no/total no (%), unless otherwise stated. OR and mean difference were calculated using patients with SVS (–) as the reference group.
*Adjusted for prespecified factors (study, age, admission NIHSS) and baseline between-group difference at P<0.10 in bivariate analysis (gender, diabetes, IVT, glycemia, site of occlusion, onset to MRI time).
†Median (IQR).
‡Common OR of improvement of 1 point in 90-day mRS score.
§13 missing values (five in SVS–).
¶Mean change (95% CI) adjusted for study and baseline values.
**Adjusted mean between-group difference.
IVT, IV thrombolysis; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction score; NIHSS, National Institutes of Health Stroke Scale; SVS, susceptibility vessel sign.