Table 1

Comparison of baseline characteristics, procedural and outcome measures in patients aged <80 years and those aged ≥ 80 years

VariableNAgeAgeTest usedTest summary
<80
(n=1000)
≥80
(n=346)
Preprocedure
 Age (years)134662 (13)85 (5)t Test<0.001
 Female (n (%))1346474 (47)230 (66)χ2 <0.01
 White (n (%))1346666 (67)240 (69)χ2 >0.05
 Pre-stroke mRS score (median (IQR))13460 (1)0 (1)MW>0.05
 Baseline NIHSS score134616 (7)17 (7)t Test<0.01
 Time from onset to groin (hours)1346399 (402)369 (527)t Test>0.05
 IV tPA (n (%))1346445 (45)168 (49)χ2 >0.05
Number of comorbidities*(median (IQR))12242 (1)2 (2)MW<0.05
   Diabetes mellitus (n (%))1224243 (27)73 (23)χ2 >0.05
   Hypertension (n (%))1224575 (63)229 (73)χ2 <0.05
   Atrial fibrillation (n (%))1224241 (27)119 (38)χ2 <0.05
   Hyperlipidemia (n (%))1224301 (33)120 (38)χ2 >0.05
 Prior stroke134659 (6)28 (8)χ2 >0.05
Location
  Anterior circulation (n (%))1346870 (87)310 (90)χ2 >0.05
  Vessel involved (n (%))1334χ2 >0.05
   ICA144 (15)50 (15)
   Tandem31 (3)13 (4)
   M1495 (50)182 (53)
   M2156 (16)55 (16)
   M325 (3)9 (3)
   Basilar106 (11)21 (6)
   Other†36 (4)11 (3)
  ASPECT score (median (IQR)) 875 8 (2)9 (3)MW<0.01
Procedure
 Time to recanalization (min)102248 (41)45 (33)t Test>0.05
 IA tPA (n (%))1298155 (16)53 (16)χ2 >0.05
 Aspiration at first pass (n (%))1336592 (59)188 (55)χ2 >0.05
 Use of stent retrievers (n (%))1336531 (53)191 (56)χ2 >0.05
 Use of additional devices‡ (n (%))1336131 (13)36 (10)χ2 >0.05
 Number of passes (Mean (Median))12992.5 (2)2.3 (2)MW<0.05
 Number of passes (n (%))1299χ2 <0.05
  <3590 (61)227 (68)
  ≥3375 (39)107 (32)
 Final TICI score (n (%))1346χ2 >0.05
  2b–3884 (88)304 (88)
  0–2a116 (12)42 (12)
 TICI score 2C–3 (n (%))1346404 (40)130 (38)χ2 >0.05
 Complications (n (%))134650 (5)15 (4)χ2 >0.05
 Hemorrhage, all types (n (%))1101251 (28)93 (42)χ2 <0.01
  Hemorrhage, PH2110133 (4)15 (7)χ2 0.07
Outcome (90 day)
 mRS (median (IQR))12263 (4)4 (3)MW<0.001
 mRS dichotomized (n (%))1226χ2 <0.001
 mRS score 0–2398 (44)65 (21)
 mRS score >2515 (56)247 (79)
 Death (n (%))1226184 (20)118 (38)χ2 <0.001
 NIHSS at discharge9198.3 (10)13 (12)t Test<0.001
 ∆NIHSS (discharge-admission)919−7.5 (10)−4 (12)t Test<0.01
 Length of hospitalization (days)109411 (12)10 (11)t Test>0.05
  • Values are n (%) or mean (SD) or median (IQR).

  • χ2Test for categorical variables, Student’s t test was used for parametric variables, or the Mann-Whitney test for non-parametric variables.

  • *Number of comorbidities includes the number of comorbidities (hypertension, hyperlipidemia, diabetes, atrial fibrillation) present in each patient and ranges from 0 to 4.

  • †Other vessels include posterior cerebral artery, anterior cerebral artery, and vertebral arteries.

  • ‡Other devices include reperfusion catheters, Penumbra separators, embolic protectors, and others.

  • ICA, internal carotid artery; mRS, modified Rankin Scale; MW, Mann-Whitney test; NIHSS, National Institutes of Health Stroke Scale; PH2, parenchymal hematoma 2; TICI, Thrombolysis in Cerebral Infarction; tPA, tissue plasminogen activator.