Table 3

Associations between the OTR interval and functional outcomes in patients with substantial reperfusion (mTICI 2b–3) and baseline ASPECTSs of 7–10

	mRS 0–1 at 90 days				mRS 0–2 at 90 days
	Unadjusted OR (95% CI)	P value	Adjusted OR (95% CI)	P value	Unadjusted OR (95% CI)	P value	Adjusted OR (95% CI)	P value
Overall patients (ASPECTS 7–10, n=269)
OTR, every 30 min delay	0.77 (0.70 to 0.85)	<0.001	0.74 (0.66 to 0.83)	<0.001	0.80 (0.73 to 0.88)	<0.001	0.79 (0.71 to 0.87)	<0.001
ITR, every 30 min delay	0.83 (0.73 to 0.94)	0.003	0.79 (0.68 to 0.91)	0.001	0.88 (0.78 to 0.99)	0.034	0.85 (0.74 to 0.97)	0.019
OTI, every 30 min delay	0.84 (0.77 to 0.93)	<0.001	0.81 (0.73 to 0.91)	<0.001	0.84 (0.77 to 0.92)	<0.001	0.83 (0.75 to 0.93)	0.001
ASPECTS 9–10 (n=157)
OTR, every 30 min delay	0.81 (0.71 to 0.91)	<0.001	0.77 (0.67 to 0.89)	0.0003	0.84 (0.75 to 0.93)	0.004	0.82 (0.71 to 0.94)	0.004
ITR, every 30 min delay	0.82 (0.70 to 0.95)	0.010	0.76 (0.64 to 0.91)	0.003	0.90 (0.77 to 1.04)	0.160	0.87 (0.73 to 1.04)	0.120
OTI, every 30 min delay	0.89 (0.78 to 1.00)	0.056	0.86 (0.75 to 0.99)	0.033	0.88 (0.77 to 0.99)	0.039	0.86 (0.75 to 0.99)	0.036
ASPECTS 7–8 (n=112)
OTR, every 30 min delay	0.71 (0.60 to 0.84)	<0.001	0.71 (0.59 to 0.85)	<0.001	0.74 (0.64 to 0.88)	<0.001	0.74 (0.63 to 0.88)	<0.001
ITR, every 30 min delay	0.78 (0.62 to 0.98)	0.031	0.80 (0.62 to 1.03)	0.082	0.77 (0.63 to 0.96)	0.019	0.81 (0.63 to 1.04)	0.092
OTI, every 30 min delay	0.80 (0.68 to 0.93)	0.004	0.75 (0.62 to 0.91)	0.003	0.83 (0.72 to 0.95)	0.008	0.78 (0.65 to 0.93)	0.006

Adjusted variables; age, sex, baseline NIHSS, atrial fibrillation, target occlusion location, and OTR (ITR or OTI) (including the baseline ASPECTS in the analysis of overall patients).
P=0.51, no significant interaction between individual ASPECTSs (10, 9, 8 and 7) and the OTR.
P=0.38, no significant interaction between two ASPECTS (9–10, 7–8) categories and the OTR.
ITR, imaging to reperfusion time; OTI, onset to imaging time; OTR; onset to reperfusion time.