Patient and aneurysm characteristics for the eight included studies assessing Pipeline Flex treatment of unruptured intracranial aneurysms
| Study variable | Martinez-Galdamez, 201814 | Brasilien-se et al, 201821 | Lin et al, 201813 | Colby et al, 20189 | Oishi et al, 201722 | Le et al, 20174 | Hanel et al, 201720 | Pereira et al, 20158 | Total | I2 or µ±SE |
| Prospective | Yes | No | No | No | No | No | Yes | Yes | ||
| Continent | Europe | North America | North America | North America | Asia | North America | North America | North America | ||
| Centers (n) | 7 | 9 | 1 | 1 | 1 | 1 | 22 | 1 | 43 | |
| Patients (n) | 50 | 205 | 47 | 294 | 94 | 38 | 141 | 10 | 879 | |
| Treatments (n) | 50 | 205 | 47 | 316 | 94 | 38 | 141 | 10 | 901 | |
| Aneurysms (n) | 50 | 223 | 47 | 316 | 94 | 38 | 141 | 12 | 935 | I2 |
| Small (<10 mm) | 38 | 127 | 45 | 265 | 0 | 46 | 141* | 9 | 671 (72%)* | 98.9% |
| Large (10–24 mm) | 11 | 89 | 2 | 46 | 84 | 0 | 0 | 3 | 235 (25%) | 98.2% |
| Giant (≥25 mm) | 1 | 7 | 0 | 5 | 16 | 0 | 0 | 0 | 29 (3%) | 81.9% |
| Anterior circulation | 47 | 193 | 47 | 316 | 100 | 43 | NR | 12 | 758 (95%) | 92.1% |
| Posterior circulation | 3 | 30 | 0 | 0 | 0 | 3 | NR | 0 | 36 (5%) | 92.1% |
| ICA (all) | 47 | 193 | 47 | 238 | 100 | 41 | NR | 12 | 657 (83%) | |
| Cervical/petrous | 0 | 5 | 1 | 8 | 0 | 0 | NR | 0 | 14 (2%) | |
| Cavernous | 9 | 27 | 1 | 30 | 51 | 4 | NR | 3 | 125 (16%) | |
| Paraophthlamic | 24 | 96 | 33 | 131 | 49 | 30 | NR | 7 | 370 (47%) | |
| Communicating | 14 | 44 | 5 | 62 | 0 | 7 | NR | 2 | 134 (17%) | |
| Terminus | 0 | 6 | 1 | 7 | 0 | 0 | NR | 0 | 14 (2%) | |
| Distal to ICA | 0 | 15 | 6 | 78 | 0 | 2 | 0 | 0 | 101 (11%) | |
| Vertebral/PICA | 3 | 24 | 0 | 0 | 0 | 3 | NR | 0 | 30 (4%) | |
| Basilar/PCA | 0 | 6 | 0 | 0 | 0 | 0 | NR | 0 | 6 (<1%) | |
| Previous rupture | 6 | 19 | 10 | 55 | 1 | 0 | NR | 0 | 91 (11%) | 88.1% |
| Symptomatic | 6 | 86 | NR | NR | 40 | 0 | NR | 0 | 132 (31%) | |
| Saccular/irregular | 47 | 186 | NR | NR | NR | NR | NR | 11 | 244 (86%) | |
| Fusiform | 3 | 27 | NR | NR | NR | NR | NR | 1 | 31 (11%) | |
| Dissecting | 0 | 10 | NR | NR | NR | NR | NR | 0 | 10 (3%) | |
| Part thrombosed | NR | NR | NR | NR | NR | NR | NR | 1 | 1 | |
| Female (% of treatments) | 41 (82.0%) | 165 (80.5%) | 40 (85.1%) | 258 (81.6%) | 84 (89.4%) | 32 (84.2%) | 124 (87.9%) | 8 (80%) | 752 (83.4%) | 11.1% |
| Adjunct coiling | 7 | 25 | 3 | 29 | 34 | 2 | NR | 2 | 13% | 84.3% |
| Angioplasty | 9 | 36 | 12 | 47 | NR | 1 | NR | 1 | 16% | 55.1% |
| Abciximab | 0 | 9 | 3 | 17 | NR | 2 | NR | 0 | 5% | 14.0% |
| Mean±SD dome diameter, mm | 8.8±6.2 | 8.2±6.4 | 4.8±2.7 | 6.3±5.2 | 16.9±3.4 | 4.3±1.7 | 5.0±1.9 | 8.8±1.2 | µ±SE 7.98±1.45 | |
| Mean±SD age, years | 53.0±13.0 | 55.7±14.4 | 57.3±11.6 | 57.7±12.3 | 63.4 (NR) | 54.2±11.2 | 54.6 (NR) | 57.7 (NR) | 56.7±1.14 | |
| Mean±SD devices per patient | 1.10±0.27 | 1.32±0.24 | 1.28±0.45 | 1.14±0.34 | 1.51 (NR) | 1.03±0.16 | 1.1 (NR) | 1.2±0.42 | 1.20±0.06 |
*All aneurysms from Hanel et al, 2017 were <12 mm diameter, with a maximal diameter of 11.1 mm. Specific data for aneurysms <10 mm were not available from this study.
ICA, internal carotid artery; µ, mean; NR, not reported; PICA, posterior inferior cerebellar artery; PCA, posterior cerebral artery.