Table 3

Subgroup analysis of various imaging and study characteristics

Study CharacteristicTOF-MRACE-MRA
Sensitivity
(95% CI)
Specificity
(95% CI)
Positive LR (95% CI)Negative LR (95% CI)Sensitivity (95% CI)Specificity (95% CI)Positive LR (95% CI)Negative LR
(95% CI)
2D DSA0.85
(0.82 to 0.89)
0.92
(0.89 to 0.94)
9.04
(5.24 to 15.59)
0.18
(0.11 to 0.29)
0.86
(0.79 to 0.91)
0.94
(0.91 to 0.96)
11.74
(5.38 to 25.59)
0.22
(0.11 to 0.43)
3D DSA0.88
(0.84 to 0.92)
0.94
(0.91 to 0.96)
9.51
(4.07 to 22.19)
0.16
(0.09 to 0.30)
0.80
(0.72 to 0.86)
0.88
(0.78 to 0.94)
4.17
(1.74 to 10.00)
0.20
(0.08 to 0.50)
1.5T MRA0.87
(0.83 to 0.90)
0.93
(0.91 to 0.95)
11.21
(6.27 to 20.06)
0.17
(0.10 to 0.29)
0.91
(0.86 to 0.95)
0.94
(0.90 to 0.96)
10.33
(5.21 to 20.47)
0.14
(0.07 to 0.27)
3T MRA0.86
(0.82 to 0.90)
0.92
(0.88 to 0.94)
7.16
(3.42 to 14.98)
0.19
(0.11 to 0.32)
0.73
(0.64 to 0.81)
0.92
(0.86 to 0.96)
5.75
(2.43 to 13.58)
0.34
(0.20 to 0.60)
GRADE 1–20.95
(0.89 to 0.98)
0.88
(0.80 to 0.93)
13.58
(1.60 to 115.39)
0.09
(0.04 to 0.17)
GRADE 3–40.88
(0.85 to 0.90)
0.95
(0.94 to 0.96)
10.18
(6.06 to 17.10)
0.18
(0.12 to 0.27)
0.88
(0.84 to 0.91)
0.96
(0.94 to 0.97)
9.85
(4.26 to 22.82)
0.17
(0.09 to 0.34)
Prospective0.84
(0.81 to 0.87)
0.92
(0.9 to 0.94)
7.39
(4.43 to 12.31)
0.21
(0.15 to 0.32)
0.82
(0.76 to 0.87)
0.92
(0.88 to 0.95)
6.81
(3.54 to 13.12)
0.24
(0.14 to 0.41)
Retrospective0.93
(0.90 to 0.95)
0.97
(0.96 to 0.98)
16.84
(8.22 to 34.49)
0.11
(0.05 to 0.22)
0.94
(0.90 to 0.96)
0.98
(0.97 to 0.99)
23.10
(5.01 to 106.56)
0.09
(0.02 to 0.40)
  • CE, constrast-enhanced; GRADE, Grades of Recommendation, Assessment, Development, and Evaluation; MRA, magnetic resonance angiography; TOF, time-of-flight.