Table 3

Baseline and interventional differences of patients with futile and non-futile reperfusion

Futile recanalization (n=70)Non-futile recanalization (n=79)P value
Clinical items
 Age (years)74 (63–81), N=7067 (57–79), N=790.025
 Transfer from another hospital34/70 (48.6%)37/79 (46.8%)0.870
 Sex (female)34/70 (48.6%)30/79 (38.0%)0.246
 NIHSS score on admission21 (12–36), N=6512 (6–23), N=750.002
 Prestroke independence60/70 (85.7%)75/79 (94.9%)0.089
 Blood pressure systolic (mm Hg)154 (SD 32), N=41144 (SD 28), N=390.170
 Blood pressure diastolic (mm Hg)78 (SD 17), N=4178 (SD 15), N=390.840
 Admission glucose (mmol/L)7.6 (6.3–9.3), N=457.4 (6.4–9.8), N=410.959
 Noticed symptom onset50/70 (71.4%)62/79 (78.5%)0.347
 Wake up7/70 (10.0%)5/77 (6.5%)0.551
 In-hospital stroke2/70 (2.9%)0/790.219
Medication0.417
 Antiplatelet
  Monotherapy17/67 (25.4%)14/75 (18.7%)
  Dual therapy0/670/75
 Statin15/63 (23.8%)12/69 (17.4%)0.394
 Anticoagulation0.401
  None63/67 (94.0%)69/75 (92.0%)
  VKA4/67 (6.0%)4/75 (5.3%)
  NOAC0/672/75 (2.7%)
Risk factors
 Diabetes10/69 (14.5%)9/79 (11.4%)0.628
 Arterial hypertension36/69 (52.2%)40/79 (50.6%)0.870
 Dyslipidemia26/67 (38.8%)26/79 (32.9%)0.491
 Smoking16/65 (24.6%)25/74 (33.8%)0.267
 Previous stroke8/67 (11.9%)8/79 (10.1%)0.794
 Coronary artery disease11/35 (31.4%)4/40 (10.0%)0.040
 TOAST etiology
0.286
  Large artery13/69 (18.8%)21/79 (26.6%)
  Cardioembolic27/69 (39.1%)33/79 (41.8%)
  Other specific etiology4/69 (5.8%)7/79 (8.9%)
  Unknown etiology25/69 (36.2%)18/79 (22.8%)
Type of imaging1.000
 MRI16/70 (22.9%)19/79 (24.1%)
 CT54/70 (77.1%)60/79 (75.9%)
 pcASPECTS7 (5–9), N=258 (7–9), N=240.076
Treatment
 IVT use29/70 (41.4%)33/79 (41.8%)1.000
 Time from onset of symptoms to IVT needle (min)165 (117–225), N=21/29178 (109–228), N=16/330.914
 Time from onset of symptoms to admission (min)240 (122–446), N=55222 (112–335), N=670.231
 Time from onset of symptoms to groin puncture (min)305 (211–539), N=55300 (200–450), N=670.365
 Time groin to recanalization (min)47 (34–86), N=6741 (28–68), N=760.096
 General anesthesia61/70 (87.1%)68/77 (88.3%)1.000
 Additional intra-arterial thrombolytic agents11/70 (15.7%)4/76 (5.3%)0.055
 Balloon-guiding catheter2/70 (2.9%)7/76 (9.2%)0.169
 Intracranial stent17/70 (24.3%)7/79 (8.9%)0.014
 Extracranial stent3/70 (4.3%)8/79 (10.1%)0.219
 Any interventional complication7/70 (10.0%)6/79 (7.6%)0.773
 Maneuver1 (1–2), N=451 (1–2), N=500.016*
 sICH ECASS II2/70 (2.9%)2/79 (2.5%)1.000
  • *Maneuver count higher in futile recanalization.

  • IVT, intravenous thrombolysis; NIHSS, National Institutes of Health Stroke Scale; NOAC, non-vitamin K antagonist oral anticoagulants; pcASPECTS, posterior circulation Alberta Stroke Program Early CT Score; sICH, symptomatic intracranial hemorrhage according to the European Cooperative Acute Stroke Study II definition; TOAST, Trial of ORG 10172 in Acute Stroke Treatment; VKA, vitamin K antagonist.Difference in numbers of observations and total numbers of patients in each group due to missing data items.