Primary outcomes for all patients
| Primary workflow outcomes (min), median (Q1–Q3) | Transfer | Direct | P value (unadjusted) | P value (adjusted)* |
| All patients | ||||
| Scene departure to alteplase | 62.3 (49.5–85.1) | 50.2 (42.3–63.0) | <0.01 | 0.008 |
| Scene departure to arterial puncture | 152.2 (116.1–192.0) | 93.0 (66.8–127.4) | <0.01 | 0.004 |
| Matched pairs | ||||
| Scene departure to alteplase | 59.3 (42.2–84.2) | 51.0 (43.0–64.0) | 0.18 | 0.18 |
| Scene departure to arterial puncture | 136.7 (111.4–192.0) | 97.0 (71.0–128.0) | <0.01 | 0.003 |
| Primary clinical outcomes | Modified Rankin Scale score at 90 days mean (95% CI) | Odds ratio (95% CI) for less disability | |||
| All patients | 3.4 (3.2 to 3.6) | 3.0 (2.7 to 3.2) | 1.29 (1.04 to 1.60) | 0.012 | 0.02 |
| All patients (independent pre-stroke) | 2.8 (2.5 to 3.0) | 2.2 (1.9 to 2.5) | 1.47 (1.13 to 1.93) | 0.003 | 0.006 |
| Matched pairs | 3.6 (2.9 to 4.2) | 2.7 (2.1 to 3.3) | 1.9 (1.03 to 3.31) | 0.019 | 0.02 |
| Matched pairs (independent pre-stroke) | 2.7 (2.1 to 3.4) | 1.7 (1.3 to 2.3) | 2.06 (1.10 to 3.89) | 0.13 | 0.1 |
↵*False discovery rate was controlled for primary outcomes using the Benjamini–Hochberg procedure, with a false discovery rate of 0.05.