Number of eligible patients and percentage of large vessel occlusion in studies included in the systematic review*
| Author, year | Method of AIS denominator determination | Denominator (suspected AIS) (n) | Denominator (n) | No of LVOs (n (%)) | LVO based on suspected AIS (%) |
| Mokin et al, 201812 | Medical charts, type of codes used to pull out charts not specified | 1592 | 989 | 224 (23) | 14 |
| Rai et al, 201821 | ICD-9 codes used to identify hospital discharges with stroke | - | 2739 | 440 (16) | - |
| McMeekin et al, 201711 | AIS patients in the prospective stroke registry. Clinical diagnosis of AIS with CT negative for hemorrhage | 95 500 | 83 090 | 33 230 (40) | 35 |
| Demeestere et al, 20175 | AIS patients identified by EMS | 551 | 381 | 199 (52) | 36 |
| Dozois A et al, 20176 | AIS patients identified by EMS | 777 | 485 | 117 (24) | 15 |
| Turc et al, 201615 | AIS proven by MRI or late CT | - | 1340 | 336 (25) | - |
| Chia et al, 201620 | AIS diagnosed with MRI, CT, or physician consensus | 318 | 258 | 33 (13) | 10 |
| Beumer et al, 20164 | Erasmus Stroke Registry (diagnosis by neurologist) | - | 338 | 106 (31) | - |
| Vanacker et al, 201616 | AIS registry (diagnostic criteria unclear) | - | 2493 | 619 (25) | - |
| Lima et al, 201617 | Clinical diagnosis of AIS in the ED | - | 727 | 240 (33) | - |
| Hansen et al, 20157 | Clinical diagnosis of AIS on admission | 885 | 475 | 176 (37) | 20 |
| Gonzalez et al, 201319 | Clinical diagnosis of AIS on admission | - | 649 | 221 (34) | - |
| Heldner et al, 20138 | Clinical diagnosis at AIS referral center | 2152 | 2018 | 860 (43) | 40 |
| Mattioni et al, 201310 | Clinical diagnosis of AIS | - | 220 | 76 (35) | - |
| Henninger et al, 20129 | Imaging confirmed AIS | 1153 | 541 | 115 (21) | 10 |
| Olvarria et al, 201013 | Imaging confirmed AIS | 836 | 465 | 104 (22) | 12 |
| Smith et al, 200918 | Clinical diagnosis by stroke neurologist | 735 | 578 | 267 (46) | 36 |
| Torres et al, 200818 | Discharge diagnosis of AIS | 230 | 205 | 56 (27) | 24 |
*7 of the 18 studies did not report the number of suspected AIS patients; therefore, the percentage of LVO based on suspected AIS could not calculated.
AIS, acute ischemic stroke; ED, emergency department; EMS, emergency medical services; ICA, internal carotid artery; ICD, International Classification of Diseases; LVO, large vessel occlusion.