Table 1

Outcomes after mechanical thrombectomy (MT) and medical management of acute ischemic stroke patients with Alberta Stroke Program Early CT Score (ASPECTS) ≤6

VariablesEVT groupNo of articlesControl groupNo of articlesP value
Clinical and angiographic outcomes among MT and control groups
 Overall rate of mRS 0–2 
at 90 days FU
353/1194=30.1%
(95% CI 21.7% to 38.5%) (I2=92.4%)
1710/184=3.2%
(95% CI 0.7% to 7%) (I2=64.3%)
5<0.001*
 Mortality rate at 90 days FU406/1146=33.8%
(95% CI 21% to 45%)
I2=94%)
1677/149=47.7%
(95% CI 32.3% to 63%)
I2=72%)
4<0.001*
 Rate of symptomatic ICH254/1146=20%
(95% CI 11% to 28%)
I2=95%)
1361/149=31.7%
(95% CI 9% to 72%)
I2=98%)
40.05*
 TICI 2b–3 revascularization673/978=69.5%
(95% CI 56% to 80%)
(I2=94%)
11NANANA
Comparison between MT group and control group (OR meta-analysis)
 Rate of mRS 0–2 at 90 days FUOR 4.76
31/149 vs 10/184 (95% CI 1.3 to 16.8)
(I2=31%)
50.01
 Mortality rate at 90 days FUOR 0.86
58/127 vs 77/149 (95% CI 0.2 to 3.4)
(I2=79%)
40.8
 Rate of symptomatic ICHOR 0.48
32/127 vs 61/149 (95% CI 0.22 to 1.05)
(I2=0%)
40.06
Comparison between patients with recanalization (TICI 2b–3) versus no recanalization after MT (OR meta-analysis)
 mRS 0–2 at 90 daysOR 5.3
197/535 vs 30/274 (95% CI 2.7 to 10)
(I2=49%)
50.001
 Rate of symptomatic ICHOR 0.77
96/344 vs 65/200 (95% CI 0.48 to 1.2)
(I2=12%)
50.2
  • *The two-proportions z-test was used.CI, confidence interval; EVT, endovascular treatment; FU, follow-up; I2; heterogeneity; ICH, intracranial hemorrhage; mRS, modified Rankin Scale; MT, mechanical thrombectomy; OR, odds ratio; TICI, Thrombolysis in Cerebral Infarction.