Table 1

Demographics, clinical, and radiological characteristics of patients eligible for late EVT according to trial (DAWN and/or DEFUSE-3) and liberal criteria

VariableTrial-eligible group
(n=52)
Liberal-eligible group
(n=103)
ORR (95% CI)
Trials/Liberal
Age, years67.7 (22.6)72.3 (22.0)0.99 (0.98 to 1.00)
Sex, F29 (55.6%)53 (51.5%)1.19 (0.75 to 1.89)
Pre-stroke mRS0 (1)0 (1)0.89 (0.72 to 1.11)
Stroke characteristics
 NIHSS on admission15 (8)15 (9)0.98 (0.96 to 1.00)
 Visual field defects35 (67.3%)64 (62.1%)1.11 (0.67 to 1.85)
 Aphasia27 (51.9%)53 (52.0%)0.93 (0.59 to 1.49)
 Neglect22 (42.3%)37 (36.6%)1.20 (0.76 to 1.89)
 Vigilance impairment8 (15.4%)24 (23.5%)0.52 (0.26 to 1.04)
 Wake-up stroke32 (61.5%)55 (53.4%)1.43 (0.88 to 2.33)
Process measures
 LPGH-to-arrival time, min577 (316)526 (363)1.01 (0.97 to 1.04)
 LPGH-to-CT time, min615 (304)587 (379)1.08 (1.00 to 1.15)
Pre-stroke treatments
 Antiplatelet16 (30.8%)34 (33.0%)0.89 (0.54 to 1.47)
 Anticoagulation7 (13.5%)9 (8.7%)1.69 (0.94 to 3.03)
 Antihypertensive27 (52.9%)56 (55.5%)0.90 (0.56 to 1.43)
 Statin14 (27.5%)27 (26.7%)1.04 (0.62 to 1.75)
Vascular risk factors
 Hypertension30 (57.7%)60 (58.8%)0.96 (0.60 to 1.54)
 Diabetes5 (9.6%)16 (15.7%)0.56 (0.25 to 1.23)
 Hyperlipidaemia20 (39.2%)45 (44.6%)0.78 (0.48 to 1.27)
 Current smoking9 (17.7%)23 (22.6%)0.74 (0.38 to 1.41)
Radiological variables
 ASPECTS8 (2)9 (2) 0.93 (0.87 to 0.99)*
 ICA occlusion16 (30.1%)25 (24.3%)1.20 (0.69 to 2.13)
 M1 occlusion†44 (84.6%)56 (54.4%) 4.17 (2.04 to 9.09)*
 Proximal M2 occlusion†37 (71.1%)68 (66.0%)1.01 (0.58 to 1.74)
 Basilar artery occlusion0 (0%)10 (9.7%)NA
 Infarct volume, mL16.1 (32.8)13.4 (39.0) 1.07 (1.02 to 1.11)*
 Penumbra volume, mL106.5 (61.6)90.5 (84.6) 1.06 (1.02 to 1.10)*
 MR6.0 (17.1)4.3 (15.5) 1.01 (1.01 to 1.02)*
 Good collaterals17 (36.1%)33 (34.4%)0.82 (0.47 to 1.43)
TOAST mechanism
 Atherosclerotic10 (20.4%)16 (16.3%)1.32 (0.69 to 2.56)
 Cardioembolism22 (44.9%)44 (44.9%)0.95 (0.58 to 1.54)
 Undetermined (including ESUS)13 (26.5%)29 (29.6%)0.83 (0.48 to 1.45)
Real EVT
 Late EVT performed14 (26.9%)27 (26.2%)1.49 (0.76 to 2.92)
 LPGH-to-groin puncture, min643 (145)641 (300)1.03 (0.97 to 1.10)
Favourable outcome
 In all patients25 (50.0%)48 (48.0%)1.20 (0.74 to 1.96)
 In patients with EVT8/12 (66.7%)14/24 (58.3%)2.04 (0.39 to 11.1)
  • Results from the univariate analysis between trial and liberal-eligible patients are presented as ratios of odds ratios (ORR) and their 95% CI.

  • *Denotes significant results.

  • †With or without more proximal occlusion.

  • ASPECTS, Alberta Stroke Program Early CT Score; EVT, endovascular treatment; ICA, internal carotid artery; LPGH, last proof of good health; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; ORR, ratio of odds ratios.