Prevalence of clinical core mismatch over time and ASPECTS
| (A) LVO and NIHSS ≥10 | P value | Rate of mismatch decay (per hour) | |||||||||
| 0–24 hours | 0–3 hours | 3–6 hours | 6–9 hours | 9–12 hours | 12–15 hours | 15–18 hours | 18–21 hours | 21–24 hours | 0–24 hours | ||
| % CCM | 63% | 53% | 66% | 41% | 43% | 56% | 29% | 25% | 53% | 0.03 | 1.6% |
| % CCM (witnessed) | 62% | 55% | 77% | 40% | 40% | 50%* | 60% | 0.26 | |||
| (B) LVO and NIHSS ≥10 and rCBF/MRI <120 min of CT head | Rate of mismatch decay (per ASPECTS) | ||||||||||
| ASPECTS | 9–10 | 6–8 | 0–5 | ||||||||
| % CCM | 77% | 65% | 13% | <0.01 | 6.4% | ||||||
| (C) Relationship between mismatch, time, and ASPECTS (% CCM) | Rate of mismatch decay (per ASPECTS point by time window) | ||||||||||
| ASPECTS | 9–10 | 6–8 | 0–5 | ||||||||
| % CCM | 0–6 hours | 65% | 65% | 13% | 0.03 | 5.3% | |||||
| 6–12 hours | 92% | 67% | 20% | 0.01 | 7.2% | ||||||
| 12–24 hours | 81% | 60% | 10% | 0.002 | 7.1% | ||||||
| P value | 0.17 | 1 | 1 | NA | |||||||
| Rate of mismatch decay (per time by ASPECTS groups) | No trend of decay | ||||||||||
*Grouped together due to small numbers.
ASPECTS, Alberta Stroke Program Early CT Score; CCM, clinical-core mismatch; LVO, large vessel occlusion; NIHSS, National Institutes of Health Stroke Scale; rCBF, relative cerebral blood flow.