Independent predictors for late EVT eligibility according to trial and liberal criteria in late-arriving patients with AIS (n=925)
| Predictors | Trial (DAWN and/or DEFUSE-3) eligibility | Liberal eligibility | ||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Pre-stroke mRS | – | – | 0.64 (0.48 to 0.86) | <0.01 |
| Hypercholesterolemia | – | – | 2.79 (1.43 to 5.46) | <0.01 |
| NIHSS | – | – | 1.12 (1.07 to 1.16) | <0.01 |
| Eye deviation | 2.94 (1.44 to 6.01) | <0.01 | 2.06 (1.08 to 3.92) | 0.03 |
| Visual field defects | 2.75 (1.32 to 5.70) | 0.01 | – | – |
| Hemiparesis | 4.72 (1.10 to 20.30) | 0.04 | – | – |
| LPGH-to-arrival time | 0.95 (0.91 to 0.98) | <0.01 | 0.94 (0.91 to 0.97) | <0.01 |
Only significant results are shown. The model for liberal eligibility also included the variables known onset, statin use, smoking, and systolic blood pressure on admission, which were included to obtain a good calibration of the model according to the Hosmer–Lemeshow test. The time unit for LPGH-to-arrival time is 30 min.
AIS, acute ischemic stroke; EVT, endovascular treatment; LPGH, last proof of good health; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.