Baseline characteristics of the study cohort
| Characteristics | Value |
| Age, years, (mean (SD)) | 68 (15) |
| Female | 677/1360 (50) |
| White | 795/1355 (59) |
| Medical history | |
| Diabetes | 430/1360 (32) |
| Hypertension | 854/1361 (63) |
| Atrial fibrillation | 500/1360 (37) |
| Hyperlipidemia | 534/1361 (39) |
| Admission variables | |
| Baseline mRS (median (IQR)) | 0 (1) |
| Admission NIHSS score, (median (IQR)) | 15 (9) |
| Onset to Groin (min) (median (IQR)) | 216 (174) |
| Onset to groin <6 hours | 1094/1303 (84) |
| ASPECTS (median (IQR)) | 9 (2) |
| IV tPA (N (%)) | 760 (55) |
| Admission SBP (mean (SD)) | 143 (27) |
| Mean SBPr (mean (SD)) | 7% (16%) |
| Etiology | |
| Large artery atherosclerosis | 227/1342 (17) |
| Cardioembolic | 681/1342 (51) |
| Cryptogenic | 365/1342 (27) |
| Other | 69/1342 (5) |
| Endovascular treatment | |
| Location of occlusion | |
| ICA | 230/1359 (17) |
| Tandem occlusion | 110/1359 (8) |
| M1 | 763/1359 (56) |
| Distal occlusion | 255/1359 (19) |
| mTICI 3 | 729/1360 (54) |
| Antihypertensive treatment within 24 hours † | 549/1009 (54) |
| Outcomes | |
| 90-Day mRS 3–6 | 703/1361 (52) |
| 90-Day mortality | 221/1361(16) |
| sICH | 70/1358 (5) |
| Hemicraniectomy* | 48/1136(4) |
*available from 9/10 centers.
†Available from 8/10 centers.
ASPECTS, Alberta Stroke Program Early CT Score; ICA, Internal carotid artery; IV tPA, intravenous tissue plasminogen activator; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction score; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure; SBPr, systolic blood pressure reduction; sICH, symptomatic intracerebral hemorrhage.