Table 1

Baseline characteristics, procedural and outcome parameters according to the subgroups of patients, ASPECTS <6 versus ASPECTS ≥6

ASPECTS <6ASPECTS ≥6P value
Baseline characteristics
 Age (years) – median (IQR)73 (60–80)
(n=152)
76 (64–82)
(n=1548)
0.041*
 Female – % (n)42.1 (64/152)51.9 (804/1700)0.022*
 Risk factors – % (n)
  Arterial hypertension67.5 (102/151)75.5 (1161/1537)0.039*
  Hyperlipidemia29.1 (44/151)33.1 (507/1537)0.364
  Diabetes mellitus18.5 (28/151)21.2 (326/1541)0.529
  Atrial fibrillation35.8 (54/151)41.3 (634/1536)0.194
  Smoking13.0 (18/138)15.6 (217/1387)0.697
 Stroke etiology – % (n)0.239
  Atrial fibrillation50.3 (76/151)51.1 (781/1529)
  Atherosclerosis24.5 (37/151)25.8 (395/1529)
  Dissection4.0 (6/151)1.6 (25/1529)
  Other6.0 (9/151)4.2 (64/1529)
  Undetermined15.2 (23/151)17.3 (264/1529)
Baseline NIHSS – median (IQR)17 (14–20)
(n=151)
15 (10–18)
(n=1534)
<0.001*
Pre-stroke mRS >1 % (n)17.0 (25/147)19.5 (292/1499)0.512
Ship – % (n)54.6 (83/152)46.4 (718/1548)0.061
Mothership – % (n)45.4 (69/152)53.6 (830/1548)0.061
Intravenous thrombolysis – % (n)47.4 (72/152)57.3 (883/1540)0.020*
Side of vessel occlusion (right) - % (n)58.6 (89/152)47.4 (730/1541)0.011*
NIHSS 24 hours - median (IQR)19 (12–27)
(n=139)
10 (4–19)
(n=1375)
<0.001*
mRS 24 hours – median (IQR)5 (5–5)
(n=143)
5 (3–5)
(n=1331)
<0.001*
NIHSS discharge – median (IQR)13 (5–19.75)
(n=96)
5 (2–12)
(n=1255)
<0.001*
mRS discharge – median (IQR)5 (4–6)
(n=151)
4 (2–5)
(n=1521)
<0.001*
Workflow times
Symptom onset to groin puncture (min) – median (IQR)212.5 (173.5–266.25)
(n=76)
192 (135.5–269)
(n=913)
0.023*
Symptom onset to recanalization (min) – median (IQR)264 (213–323)
(n=65)
241 (180–320)
(n=779)
0.032*
Procedural and outcome parameters
mTICI 2b/3 – % (n)74.3 (113/152)83.0 (1272/1533)0.010*
Any ICH within 24 hours – % (n)22.4 (34/152)14.1 (219/1548)0.012*
mRS 0–2 at 90 days – % (n)21.7 (33/152)38.0 (588/1548)<0.001*
mRS 5/6 at 90 days – % (n)57.2 (87/152)36.0 (558/1548)<0.001*
mRS 6 at 90 days – % (n)44.7 (68/152)27.1 (419/1548)<0.001*
mRS at 90 days – median (IQR)5 (3–6)
(n=152)
3 (1–6)
(n=1548)
<0.001*
  • *significant

  • ASPECTS, Alberta Stroke Program Early CT Score; TICI 2b/3, modified Thrombolysis in Cerebral Infarction Score; ICH, Intracranial hemorrhage; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.