Candidate variables associated with door-to-puncture time in the primary analysis
| Candidate variable | β (95% CI) | P-value | βadj (95% CI) | P-value |
| Admission during COVID-19 period | −41.9 (-93.0 to 9.1) | 0.11 | −73.2 (-153.8 to 7.4) | 0.07 |
| Age (per tertile) | −3.0 (-39.7 to 33.8) | 0.88 | ||
| Female | 9.0 (-41.7 to 59.7) | 0.73 | ||
| Hispanic | 59.5 (-19.3 to 138.4) | 0.14 | ||
| White | 17.3 (-34.5 to 69.2) | 0.51 | ||
| Hypertension | 52.6 (-4.8 to 110.0) | 0.07 | 57.1 (-1.3 to 115.5) | 0.05 |
| Dyslipidemia | 53.2 (2.1 to 104.3) | 0.04 | 22.8 (-39.2 to 84.7) | 0.44 |
| Diabetes | 47.2 (-8.0 to 102.5) | 0.09 | 32.3 (-36.6 to 101.1) | 0.33 |
| Atrial fibrillation | 9.8 (-51.4 to 70.9) | 0.75 | ||
| Tobacco use | 49.3 (-14.8 to 113.3) | 0.13 | ||
| Prior ischemic stroke | 26.0 (-39.4 to 91.4) | 0.44 | ||
| Coronary artery disease | 32.7 (-43.7 to 109.2) | 0.40 | ||
| Transfer vs direct CSC arrival | −55.1 (-107.6 to -2.6) | 0.04 | −40.4 (-122.2 to 41.3) | 0.30 |
| High-volume center* | 13.5 (-40.3 to 67.4) | 0.62 | ||
| NIHSS (per point) | −7.2 (-11.6 to -2.8) | <0.01 | −5.9 (-13.9 to 2.1) | 0.13 |
| Intravenous thrombolysis | 24.0 (-170.6 to 122.5) | 0.75 | ||
| ICA, M1, or basilar occlusion | −26.0 (-87.6 to 35.7) | 0.41 |
Variables were included in the final multivariable model if they were significant to P<0.1 in unadjusted regression. The final multivariable model was clustered by site.
*A high-volume stroke center was defined as having performed 50 or more thrombectomies during 2019, as this volume threshold has been shown to improve treatment times.
CI, confidence interval; COVID-19, coronavirus disease 2019; EMS, emergency medical services; ICA, internal carotid artery; NIHSS, National Institutes of Health Stroke Scale.