Probabilistic sensitivity analysis results per hour of faster treatment
| Hour difference | Costs in € median (IQR) | QALY gained median (IQR) | NMB in € median (IQR) |
| First – second hour | 2633 (−10,957;18,613) | 0.36 (0.09;0.61) | 23 799 (−3004;49,133) |
| Second – third hour | −2219 (−6,651;2,240) | 0.15 (0.07;0.23) | 14 052 (6,809;21,714) |
| Third – fourth hour | −3228 (−7,274;1,026) | 0.34 (0.28;0.40) | 30 143 (23,732;36,679) |
| Fourth – fifth hour | 4666 (440;9,078) | 0.22 (0.16;0.29) | 13 125 (6,353;19,682) |
| Fifth – sixth hour | −3860 (−10,108;2,261) | 0.09 (−0.01;0.18) | 10 560 (1,708;19,971) |
| Per hour faster treatment* | −969 (−3,897;1,972) | 0.22 (0.17;0.27) | 18 513 (13,574;23,376) |
| Per 10 min faster treatment* | −151 (−649; 329) | 13.5 (10.5;16.4)† | 3085 (2,262;3,896) |
| Per minute faster treatment* | −15 (−65;33) | 1.3 (1.0;1.6)† | 309 (226;389) |
| Population outcome per hour of earlier treatment‡ | −865,387 (−5,848,900;4,459,552) | 210.1 (124.0;294.8) | 17 239 435 (8,776,181;25,712,803) |
| Population outcome per 10 min of earlier treatment‡ | −144,231 (−974,817;743,258) | 35.0 (20.7;49.1) | 2 873 239 (1,462,696;4,285,467) |
| Population outcome per minute of earlier treatment§ | −14,423 (−97,482;74,326) | 3.5 (2.1;4.9) | 287 324 (146,270;428,547) |
*For each simulation the median value of the five differences between 6 hours was taken.
†The per minute QALY results are depicted as disability-free life days gained (DALY). This is the daily value of a QALY (DALY=QALY/365).
‡Outcome for the Dutch LVO stroke population if faster EVT is performed.