Table 1

Original research manuscripts that were identified during the literature search

First
Author
Year
Study typeN with MeVO EVTNIHSS (median/mean)ASPECTS
(median/ mean)
Imaging modality usedTreatment criteriaMeVO typeTechnique usedAnesthesiaAngiographic outcomeClinical outcomesICH
Romano et al
202027
MC 44 10 9 NCCT+CTA
(±DWI if onset unknown)
NIHSS≥6
Pre-stroke mRS 0–2
ASPECTS≥6
Absence of large infarction
DWI-clinical mismatch
Contraindication to IV tPA
M2, M2/M3DAGA, CSTICI 2b/3: 91%mRS 0–2: 71%0%
Haussen et al
2020a34
SC 137 18 8/9 NCCT+CTA+CTPM2, M3
Any ACA
Any PCA
DA, SRTICI 2b/3: 84% (SR) vs 69% (DA)
TICI 3: 58% (SR) vs 46% (DA)
mRS 0–2: 45% (SR) vs 46% (DA)
Atchaneeyasakul et al 202046 MC 197 15/17 9 NCCT+CTAIsolated MeVO (absence of concurrent LVO)M2DA, SRTICI 2b/3: 90% (SR) vs 77% (DA)mRS 0–2: 52% (SR) vs 37% (DA)3% (SR) vs 5% (DA)
Jiang et al
201925
SC 37 15 10 NCCT+CTA+CTPSymptom onset ≤24 hour
NIHSS ≥6
Pre-stroke mRS 0–1
ASPECTS ≥6
Absence of large infarction
CTP mismatch ratio>1.8
M2SRCSTICI 2b/3: 95%
TICI 3: 76%
mRS. 0–2: 49%11%
Compagne et al
201923
MC 244 14 9 NCCT+CTASymptom onset ≤6.5 hourM2DA, SR, IA tPATICI 2b/3: 57%mRS 0–2: 46% mRS 0–1: 26% mRS 0: 7%7%
Gory et al 201847 RCT 79 13.4 8 M2DA, SRCS, GATICI 2b/3: 84% (SR) vs 90% (DA)
TICI 2 /3: 55% (SR) vs 54% (DA)
TICI 3: 42% (SR) vs 35% (DA)
mRS 0–2: 50% (SR) vs 54% (DA)3% (SR) vs 6% (DA)
Qureshi et al 201748 RCT 34 16 NCCT+CTAAge 18–82y tPA eligibility
Symptom onset ≤3 hour
Absence of large infarction
M2SR, IA tPATICI 2b/3: 52.6%mRS 0–2: 53% mRS 0–1: 38%6%
 Vargas et al
 201737
SC 35 14.1 NCCT+CTA+CTPContraindication to IV tPAM2, A3, combinationsDATICI 2b/3: 97%
TICI 2c/3: 83%
TICI 3: 43%
mRS 0–2: 59%3%
Sarraj et al
201649
MC 288 16 9 NCCT+CTASymptom onset ≤8 hourM2DA, SR±IA tPATICI 2b/3: 78%mRS 0–2: 63% mRS 0–1: 36% mRS 0: 14%6%
Navia et al
201629
SC 6 12,5 NCCT+CTA+CTPNIHSS≥5
ASPECTS≥8
M2, M3, P2, A2DACS and GATICI 2b/3: 100%
TICI 3: 83%
mRS 02: 100% mRS 0–1: 60% mRS 0: 20%0%
Menon et al
201924
RCT 67 14 9 NCCT+CTA (±CTP/MRI)M2SRTICI 2b/3: 59%mRS 0–2: 58% mRS 0–1: 37% mRS 0: 19%0%
Coutinho et al
201650
MC 50 13 9 NCCT+CTA (±CTP/MRI)M2SRCS, GATICI 2b/3: 85%mRS 0–2: 60% mRS 0–1: 50%2%
Grossberg et al
201845
SC 69 18.1 8 NCCT+CTA+CTPPersisting disabling deficits despite IV tPA with occlusion location accounting for the symptomsM3
Any ACA
Any PCA
DA, SRTICI 2b/3: 83%
TICI 3: 45%
mRS 0–2: 30% mRS 0–1: 13%
Nakano et al
202051
MC 51 17 8 M2DA, SRTICI 2b/3: 84%mRS 0–2: 49%3%
Altenbernd et al
201828
SC 58 15 9 NCCT+CTA+CTPAge ≥18
NIHSS ≥6
ASPECTS ≥8
M2, M3DAGATICI 2b/3: 100%
TICI 3: 83%
mRS 0–2: 95% mRS 0–1: 86% mRS 0: 35%3%
Crockett et al
201936
SC 14 8 9 A2, A3, P2, M3, SCADATICI 2b/3: 100%
TICI 2c/3: 100%
TICI 3: 91%
mRS 0–2: 63% mRS 0–1: 50% mRS 0: 43%0%
Bhogal et al
201752
SC 106 12 9 NCCT+CTA or MRIM2SRTICI 2b/3: 91%
TICI 3: 69%
mRS 0–2: 55% mRS 0–1: 45% mRS 0: 24%5%
de Castro Afonso et al
201926
SC 30 16 9 NCCT+CTASymptom onset≤6 hour or CTP mismatch if symptom onset 6–24 hour
NIHSS≥6
ASPECTS ≥6
M2DA, SR, combinationCS, GATICI 2b/3: 90%
TICI 2c/3: 60%
TICI 3: 53%
mRS 0–2: 50% mRS 0–1: 23% mRS 0: 17%7%
Grieb et al
201930
SC 52 12 NCCT+CTANIHSS ≥6 or aphasia
Absence of large infarction
M2DAGATICI 2b/3: 91%
TICI 3: 65%
mRS 0–2: 56%0%
Pérez-García et al
202053
SC 102 16 9 M2, M3, Any ACA
Any PCA
SR, combinationCS, GATICI 2b/3: 50% (SR) vs 64% (combination) TICI 2c/3: 34% (SR) vs 57% (combination)mRS 0–2: 53 (SR) vs 51% (combined)13% (SR) vs 2% (combination)
Haussen et al
2020b34
SC 22 17 8 M2CombinationTICI 2b/3: 84%
TICI 3: 64%
mRS 0–2: 40%
Pfaff et al
201654
SC 30 18 9 DWI+MRA+ PWI or NCCT+CTA+CTPSymptom onset ≤8 hour
NIHSS ≥8
ASPECTS ≥6
A2, A3, A4SRCS, GATICI 2b/3: 73%mRS 0–2: 37%0%
Styczen et al
202055
MC 15 13 10 (pcASPECTS)SCA, AICA, PICASR, DA, combination, IA tPATICI 2b/3: 88%
TICI 3: 31%
mRS 0–2: 50% mRS 0–1: 29% mRS 0: 7%
  • Note: MC = multi center, SC = single center, EEVT = endovascular treatment, MeVO = medium vessel occlusion stroke, NIHSS = National Institutes of Health Stroke Scale, (pc)ASPECTS = (posterior circulation) Alberta Stroke Program Early CT Score, CTA = CT angiography, NCCT = non contrast head CT, DWI = diffusion weighted imaging, CTP = CT perfusion, DA = direct aspiration, SR = stent retriever, IA tPA = intra-arterial alteplase, CS = conscious sedation, GA = general anesthesia, SCA = superior cerebellar artery, AICA = anterior inferior cerebellar artery, PICA = posterior infereior cerebellar artery, TICI = Thrombolysis in Cerebral Infarction Score, mRS = modified Rankin Score, sICH = symptomatic intracranial hemorrhage