Table 1

Comparison of all six ‘large core’ trials

TrialTENSIONLASTETESLARESCUE-Japan LIMITSELECT-2ANGEL-ASPECT
Official titleEfficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time WindowLarge Stroke Therapy Evaluation - ASPECTS 0–5Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic StrokeRandomized Controlled Trial of Endovascular Therapy for Acute Large Vessel Occlusion With Large Ischemic CoreA Randomized Controlled Trial to Optimize Patient’s Selection for Endovascular Treatment in Acute Ischemic StrokeStudy of EVT in Acute Anterior Circulation LVO Patients with a largE infarCT core
NCT numberNCT03094715IN EXTREMISNCT03805308NCT03702413NCT03876457NCT04551664
CountryAustria, Canada, Czechia, Denmark, France, Germany, Norway, Slovakia, SpainUSA, EuropeUnited StatesJapanUnited States
(Canada,Europe)
China
Imaging inclusion criteriaNCCT or DWI
ASPECTS 3–5
NCCT or DWI
ASPECTS 0–5
NCCT
ASPECTS 2–5
CT-ASPECTS 3–5 or DWI-ASPECTS 3–5;1. ASPECTS ≥6andcore ≥50 cc
2. ASPECTS 3–5andcore ≥50 cc
3. ASPECTS 3–5andcore <5 0cc
1. ASPECTS 3–5
2. ASPECTS >5 (>6 hour) and core 70–100 cc
3. ASPECT <3 and core 70–100 cc
NIHSS score<26>5>6≥6≥66–30
Age (years)>1818–8018–85>1818–8518–80
Time<12 hour LSW<6.5 hour LKWRandom <24 hourRandom <6 hour LKW,
6–24 FLAIR (-)
Treat <24 hour
(0–12vs6–24)
Random <24 hour
Primary outcomemRS score shift analysismRS score at 90& and 180 daysUtility-weighted 90-day mRS scoremRS score 0–3 at 90 daysShift on 90-day mRS scoremRS score at 90 days
Actual study start dateJuly 20, 2018July 16, 2019November 2018October 11, 2019September 28, 2020
Estimated primary completion dateAugust 31, 2020July 16, 2022November 2020May 1, 2021November 2022
  • Core:rCBF <30% on CT perfusion or ADC<620; Information source:https://clinicaltrials.gov. and Website.

  • ADC, apparent diffusion coefficient; ASPECTS, Alberta Stroke Program Early CT Score; DWI, diffusion-weighted imaging; FLAIR, fluid attenuated inversion recovery; LKW, last known well; LSW, last seen well; LVO, large vessel occlusion; mRS, modified Rankin Scale; NCCT, non-contrast CT; rCBF, relative cerebral blood flow.