Comparison between the groups for the first-pass effect
| NO FPE (mTICI 0–2b, n=259, 60.8%) | FPE (mTICI 2 c–3, n=167, 39.2%) | p-value | NO mFPE (mTICI 0–2a, n=205, 48.1%) | mFPE (mTICI 2b–3, n=221, 51.9%) | Pt-value | |
| Age (years), median (IQR) | 76 (65;83) | 76 (63;85) | 0.745 | 76 (66;84) | 76 (63;84) | 0.723 |
| Female gender, n (%) | 132 (51) | 87 (52.1) | 0.820 | 107 (52.2) | 112 (50.7) | 0.754 |
| NIHSS score at admission, median (IQR) | 16 (11;20) | 16 (10;19.5) | 0.204 | 16 (12;20) | 15 (10;20) | 0.092 |
| ASPECTS at admission, median (IQR) | 8 (7;9) | 9 (8;10) | <0.001 | 8 (7;9) | 9 (8;10) | <0.001 |
| Last time seen well (min), median (IQR) | 274 (165;541) | 231 (160;448) | 0.265 | 279 (171;530) | 234 (155.5;472) | 0.164 |
| IV tPA administered, n (%) | ||||||
| None | 198 (76.4) | 115 (68.9) | 0.164 | 158 (77.1) | 155 (70.1) | 0.156 |
| Partial dose | 17 (6.6) | 18 (10.8) | 12 (5.9) | 23 (10.4) | ||
| Completed dose | 44 (17.0) | 34 (20.4) | 35 (17.1) | 43 (19.5) | ||
| General anesthesia, n (%) | 68 (26.3) | 62 (37.1) | <0.001 | 55 (26.8) | 75 (33.9) | 0.008 |
| Local anesthesia, n (%) | 49 (18.9) | 45 (26.9) | 37 (18) | 57 (25.8) | ||
| Conscious sedation, n (%) | 142 (54.8) | 60 (35.9) | 113 (55.1) | 89 (40.3) | ||
| Left site occlusion, n (%) | 135 (52.1) | 90 (53.9) | 0.721 | 105 (51.2) | 120 (54.3) | 0.525 |
| Level of vessel occlusion, n (%) | 0.465 | 0.299 | ||||
| ICA carotid terminus | 49 (18.9) | 24 (14.4) | 37 (18) | 36 (16.3) | ||
| MCA–M1 | 139 (53.7) | 93 (55.7) | 117 (57.1) | 115 (52.0) | ||
| MCA–M2 | 71 27.4) | 50 (29.9) | 51 (24.9) | 70 (31.7) | ||
| BGC approach used, n (%) | 147 (56.8) | 124 (74.3) | <0.001 | 115 (56.1) | 156 (70.6) | 0.002 |
| Symptomatic intracranial hemorrhage, n (%) | 25 (12.3) | 6 (6.3) | 0.117 | 13 (6.3) | 9 (4.1) | 0.290 |
| NIHSS score at 24 hours, median (IQR) | 11(4;18) | 3 (1;7.75) | <0.001 | 12(5;19) | 3.5 (1;8) | <0.001 |
| Difference of NIHSS from admission to 24 hours, median (IQR) | 4 (0;10) | 10(4;15) | <0.001 | 3 (-1;9) | 9 (4;13.75) | <0.001 |
| mRS score 0–2 at 3 months, n (%) | 73 (47.1) | 62 (70.5) | <0.001 | 54 (42.5) | 81 (72.3) | <0.001 |
| Mortality, n (%) | 46 (29.7) | 10 (11.9) | 0.002 | 40 (31.5) | 16 (14.3) | 0.002 |
ASPECTS, Alberta Stroke Program Early CT Score; BGC, balloon guide catheter; FPE, first-pass effect; IQR, interquartile range; mRS, modified Rankin Scale; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale.